Walsh Testing and Targeted Nutrient Protocol for Treating Mood and Behavior Disorders

Second Opinion Physician is an online medical consultant and provider of individualized biochemical testing and analysis. The criteria used, for assessing and supplements protocols utilized, were researched and developed by Dr. William Walsh of the Walsh Research Institute. Dr David Epstein D.O. is a Certified Walsh Protocol Practitioner providing a detailed Assessment and Supplement Plan for each individual based on unique biochemical status.

According to Dr Walsh, as many as 95% of persons with mood imbalance and behavior disorders are experiencing a brain nutrient imbalance that can be easily tested and treated. This is the case with depression, autism, schizophrenia and alcoholism, dementia and anxiety disorders. With imbalanced nutrients, the primary neurotransmitters may be elevated or depressed.

Mood disorders can be debilitating and many folks are treated with medications that cause numerous side effects. Per the Walsh Protocol, treatment is individualized and differs greatly from person to person. For instance, supplements are significantly different for depressives who have low serotonin vs high serotonin depression.

Learn more about your own specific nutrient status and how this might affect mood disorders.

What role do nutrients play in producing neurotransmitters?

Here’s the process to get tested, diagnosed and treated per the Walsh Protocol.

If you’re new to the Walsh protocol or have questions, call or email, to schedule a free appointment with Dr Dave.

Dr David Epstein, D.O. has practiced integrative family medicine and consulting for over 25 years. As a licensed physician he is certified to administer the Walsh Protocol.

“Several years ago I had the good fortune of meeting Dr Walsh at an ACAM (American College for Advancement in Medicine) conference. He was the keynote speaker addressing an audience of integrative medical practitioners, most whom had never heard of his work before. What I learned in 45 minutes completely changed the way I look at conditions of oxidative stress, neurotransmitters and epigenetics that underlie the function of the brain.

His story, the lesson he teaches and his humble service to physicians and patients is a roadmap to treatment of mental disorders. As he continues groundbreaking research and physician training, Dr Walsh has started a movement that will one day revolutionize the practice of psychiatry. In the future, there will be very little need for drug therapies to treat conditions such as depression, schizophrenia, anxiety and dementia.  I am fully convinced that by correcting brain chemistry with nutrient therapy, per the Walsh Protocol, patients will receive the best possible treatment.” 


dr epstein walsh practitioner

Patient Testimonials

“Dear Dr Dave, I’m healthy again–and it’s been a long, difficult haul over the last four years I have been sick both physically and emotionally. Thank you for your great doctoring. Before I contacted you, I suffered thru 4 misdiagnoses, including RA for which I was treated with highly toxic drugs for 2 years! I’m now taking 100mg zinc piccolinate daily, along with 150mg B6. Should I stay at these levels? Or taper down to a maintenance dose? How much would it cost to get updated blood tests? I’m healthy and happy, but basically broke since I haven’t been working for 4 years. But I’ll find the money somehow, if I have to. Again, I deeply appreciate the work you’ve done to help me get better… Warmest regards, David”

David T.Overmethylated

“Dear Dr. Epstein, You might advise other folks to “keep the faith” because, at one point, early on, I didn’t feel any better and I got very discouraged. I’m glad I persevered. Then, about 3 months, it hit me. I felt a distinct reduction in base-line anxiety (a life-long problem from childhood). I waited 4 more days to make sure it stuck, before I told my wife, and we celebrated! The earlier problem of upset stomach and pain from the zinc gradually subsided, but it was touch-and-go for a while. The pain was intense. I reduced the dosage of zinc, and then gradually increased it back to 100mg over a couple of weeks.

PS You may be interested that, over the course of the Zinc/B6 protocol, I was able to reduce my Thyroid Meds (100mcg T4/30mcg T3. extended release) by half!! I expect there may be further reductions. I never had Hashimotos antibodies, although I was tested multiple times, which may indicate the Cu/Zn imbalance was the causative factor. I wonder how many other thousands of people with intractible Hypothyroidism have the same problem.”

Richard DElevated Free Copper

“Hello Dr Epstein, This is me again….but with wonderful news. Just to refresh your memory, Alonzo, my 9 year old son had a terrible day at school 12 days ago which was extremely discouraging for me since at that time he was already in his 7th week of taking the supplements. I thought then that maybe nothing will work. The following week I had a meeting with the principal, and explained the therapy that Alonzo was following as well as all the dietary changes, behavioral therapies already done. I also asked if we can have a partnership helping Alonzo overcome issues. She agreed to explain the teacher and proposed to implement few changes such as allowing Alonzo to sit on a wiggle sit chair cushion (great for fidgeting control: https://www.amazon.com/Wiggle-Inflatable-Sensory-Chair-Cushion/dp/B00GNOF0EI).
Thankfully, even before that meeting, Alonzo’s behavior was really improving. It got even better…to the point that the teacher herself wanted to speak to me last Friday, (I should confess I was terrified thinking that more problems had happened). It was completely the opposite. She highly praised him for his participation in class, helpfulness, and attention improvement….I was shocked!!! I never received so many complements for my kid’s behavior!! nor even while on medication!!!! I doubt myself for a moment thinking it might be a dream or my wishful thoughts what I was hearing. I even hesitate to write this email to you thinking it might revert somehow magically the positive effect….But I know is real and I’m so thankful. I understand now that my child will never be a “quiet” kid, but these supplements will help him to be the best version of himself…and, just like anyone, he will have great and bad days. However, now he will have stronger tools to control his behavior and focus better since physiologically, he is getting what he needs.

Dr. David, I know that this improvement is part of a journey, and I don’t know in which state of that journey we are now (I hope for a full recovery). I deeply thank you for your wisdom, knowledge, and availability to help us in this path to restoration. I’ll keep you posted.

God Bless you”

Rosemary LElevated Free Copper

William Walsh PhD Papers and Presentations

5 biotypes of depression walsh

Could brain scans hold the key to diagnosing mental illnesses? Test finds people with schizophrenia and bipolar disorders have biological markers

William Walsh Phd Video

Video of Dr Walsh at ANA Conference : The Five Biotypes of Depression and Advanced Nutrient Therapies with William Walsh, PhD

William Walsh depression treatment

Article Brain World: Will New Brain Biochemistry Findings Clear the Murky Waters of Depression?
Why Nutrient Therapy May Be the Answer to Depression

autism therapy william walsh phd

Autism One Video: Epigenetics and Autism Prevention – William Walsh, PhD

articles william walsh phd depression

Psychology Today: Rethinking mental disease. The future of mental health series.

William Walsh Articles

Publication in the Journal of the Australasian College of Nutritional and Environmental Medicine: The Effectiveness of Targeted Nutrient Therapy in Treatment of Mental Illness

  • Why is elevated copper or free copper a problem?

    Copper is a trace element that behaves like heavy metals when it is inadequately bound to the chelating protein ceruloplasmin. Excessive levels of unbound “free copper” affects neurotransmitters and also indicates that the body is having difficulty with free radicals and other heavy metals. 

  • Pyrrole Disorder; a cause of numerous behavioral disorders.

    Elevation of urinary pyrroles leads to chronic vitamin B6 and zinc deficiency. Zinc is essential for 100’s of processes in the body and is particularly important for healing, immune function, digestion, neurotransmitter activation, physical growth, memory, insulin sensitivity, and control of blood sugars, DNA replication and more.

    Zinc and B6 are essential for production of neurotransmitters such as serotonin (mood elevating), melatonin (sleep hormone), GABA (relaxation hormone), and acetyl choline for memory. They are involved in production of steroid hormones – cortisol and the conversion of oils in the body. The oils EPA/DHA and particularly GLA are low in those with pyrrole disorder and are damaged by oxidative stress/free radicals/toxins created by pyrrole disorder.

  • What is epigenetics?

    “Epigenetics is the natural process of gene regulation that is established in the early days of gestation in the womb. A severe environmental insult later in life can either turn off a necessary gene or turn on a damaging gene, resulting in a disorder that can persist for years.” Click here to read interview with William Walsh PhD describing his “Epigenetic Theory of Autism.”