Toxic Elements Biotype

This is an excellent summary of toxic elements and oxidative stressors due to heavy metals.

Individuals who suffer depression, anxiety or schizophrenia and other mental disorders, typically do not respond to SSRI medicines and or supplements that affect levels of serotonin and dopamine or norepinephrine. These folks may be experiencing symptoms from toxic elements, such as lead, mercury, cadmium, arsenic, copper and aluminum.

Such metals, referred to as free radicals, are environmental toxins that are inhaled from the atmosphere or consumed in foods. Cigarette smoke, incinerators, metal workers, large fish, feed additives, amalgam fillings, vaccines, paints, pastels, tattoo ink, copper cookware, well water and old paint dust etc are common sources.

While chelation therapy is used by physicians to remove metals stored in the body tissues, Dr. Walsh believes that metals are not likely to be drawn out in substantial quantities through IV chelation with products such as Calcium-EDTA. The best way to manage toxics is to supplement on a daily basis with antioxidants that capture the metals as they leave the tissue and bind or neutralize them before they are excreted in the urine or stool.

Healthy diet with antioxidants such as chlorella, fiber and vitamins D, E, A and C are most useful. Consider ALA, glutathione, gaba and zinc for more aggressive approach to toxic elements management of depression, anxiety, bipolar disorder and other mood and mental health conditions.

 

Walsh Discusses Overmethylation Biotype

 

Serious conditions such as panic disorders, Biopolar disorder and schizophrenia are often suffering from overmethylation. Serotonin, dopamine and norepinephrine are elevated in these persons. It is possible to diagnose this condition through a whole blood histamine test or else through a SAM/SAH methylation ratio test. Higher levels of these neurotransmitters can cause anxieties, disorders and in some cases psychosis and maybe lead some to suicide. Fortunately supplementation can reverse the symptoms associated with overmethylation. The goal is to reduce the methylation effect of elevated neurotransmitters and lower oxidative stress.

Dr Mercola interviews Dr Walsh; Role of nutrients for treating autism, anxiety, depression and dementia.

 

It only a matter of time before Dr Walsh and his nutritional protocol for treating mental disorders becomes mainstream. Thanks to popular health advocates such as Dr Mercola, Dr Walsh will get the exposure that is needed to wake up the medical community.

With the ever increasing ill effects on our epigenetics from the environment and the blind mis-use of medications to treat mental disorders, there is no better time than now to pay close attention to the research and perspective of Dr William Walsh in the treatment of autism, depression and all other mood and behavioral disorders.

Dr Mercola interviews Dr Walsh at a glance:

By Dr. Mercola

  • There are four biochemical types of violent people. Many have severe zinc deficiency, pyrrole disorder, low blood spermine and methylation defects — an unusual combination of bad biochemistry
  • While there are hundreds of nutrients that are important for health, in the brain, six or seven dominate. These are nutrients that are either involved in synthesis or functioning of neurotransmitters
  • Nutrients that have a powerful influence on mental health include zinc, copper, B-6, selenium, folates and S-adenosylmethionine (SAMe)

Can you use specific nutrients to improve your mental health? Yes, you can. William Walsh, Ph.D., president of the nonprofit Walsh Research Institute in Naperville, Illinois, and author of “Nutrient Power: Heal Your Biochemistry and Heal Your Brain,” specializes in nutrient-based psychiatry and nutritional medicine.

He and I are both  fellows of the American College of Nutrition. He’s designed nutritional programs for Olympic athletes, NBA players and major league baseball players. More importantly, he’s spent a great deal of his career seeking to improve mental health through nutrition.

“I started off in the hard science. I was an experimentalist,” Walsh says. “I worked, in the beginning, in the nuclear field … with places like Los Alamos, the Institute for Atomic Research and University of Michigan Research Institute. I wound up at Argonne National Laboratory. While working as a scientist there, I started a volunteer project at the local prison, Stateville Penitentiary.

I eventually got really interested in why people were violent …  [W]hen we started the ex-offender program, I got to meet the families that had produced a criminal. I found some wonderful families, caring and capable families, that have other children who turned out just fine …

I began to realize we didn’t understand why people had bad behavior. We then asked the question, ‘Could it be something related to their brain chemistry or the body chemistry?’… I started doing lab studies of their blood, their urine and hair. I found out that they were very, very different from the rest of the population. That’s how I got started.”

Biochemistry and the Criminal Brain

Walsh received valuable direction after meeting Dr. Carl Pfeiffer, who was doing work on heavy metals and schizophrenia. As it turns out, levels of metals, including copper, zinc and manganese, were all abnormal in criminals compared to the general population.

Walsh discovered four biochemical types of violent people. One of these was the sociopaths, all of whom had severe zinc deficiency, pyrrole disorder, low blood spermine and undermethylation. In all, it’s an unusual combination of bad biochemistry. A collaborative investigation with Pfeiffer resulted in nutrient therapies for each of the behavior types.

Pyrrole disorder is a stress condition commonly found in brain disorders. A urine test developed by niacin expert Abram Hoffer and Pfeiffer is the gold standard test for this genetic condition, which involves altered  biochemistry in your bone marrow and spleen.

People who have pyrrole disorder may produce five to 10 times more pyrroles than normal — a byproduct of natural reactions, like the formation of hemoglobin. While harmless in and of itself, pyrroles bind to and draw out anything that is an aldehyde, such as B-6. It also sharply depletes zinc.

As a result, people with pyrroles disorder have exceptionally low levels of B-6, and zinc which can have serious effects on brain function, affecting their memory and ability to read, for example. B-6 deficiency is quite common among children with attention deficit hyperactivity disorder (ADHD) as well.

The Earlier the Treatment the Better the Results

“Eventually, [Pfeiffer] and I jointly evaluated 500 patients, mostly violent adults and violent children. We got our best results with the kids, young people with the same kind of chemistry, who were mostly very violent,” Walsh says.

“I have to say we didn’t really succeed in finding a way to help the adult criminals. They would get better for six to eight months, and then I’d find out they were back in prison. That had a lot to do with the fact that they were abusing alcohol and illegal drugs … At about 1990, we decided to focus on children …

It’s been very successful. If we can get a child before their lives are ruined, before they pass puberty perhaps, our success rate [is] very high … The doctors report a striking improvement in behavior. Most of these kids, of course, [are] on drugs, everything from Ritalin to powerful antipsychotic  medications. Usually when we’re finished and [have] balanced their chemistry, they can wean off the medication. They usually are fine without it …”

Nutrients Involved in Synthesis or Functioning of Neurotransmitters Dictate Mental Function

Later on, Walsh expanded to also include children with autism and ADHD. Fond of numbers, Walsh began amassing enormous databases. At present, he has one of the world’s largest chemistry database for autismdepression and behavior disorders.

“When you look at these millions of chemical analyses of blood, urine and tissues, it’s obvious that there are very great differences,” he says. “I found that for mental disorders, about six or seven chemical imbalances dominate mental function. There are hundreds and hundreds of important nutrients in the body, but in the brain, there are about six or seven that [seem] to dominate everything. Eventually, I found out why …

[T]hese are the nutrient factors that are either involved in synthesis of a neurotransmitter or the functioning of a neurotransmitter. They include methylation — undermethylation or overmethylation. In our database, 70 percent of all humans in the United States have normal, typical methylation; 22 percent are undermethylated … 8 percent are overmethylated.

About 70 percent of all people who have a mental disorder have one of these methylation disorders. The symptoms are completely different, and the treatment they need is completely different. We also found that most people [who have mental disorders] are depleted or deficient in zinc. That’s the most common [deficiency] we see … Virtually everyone with a mental disorder seems to need zinc and improve on it.”

Copper Overload Linked to Autism, Schizophrenia and Postpartum Depression

Copper is another important trace metal, as it plays a distinct role in the synthesis of norepinephrine, a major neurotransmitter. Divalent copper (Cu2+) is a dramatic factor in the ratio of dopamine and norepinephrine. Read more here…

The Importance of Methylation and Folates in Mental Health

Walsh was among the first people to alert the world to the importance of methylation in mental health, especially autism. The No. 1 causes of undermethylation are single-nucleotide polymorphisms (SNPs) or mutations in the enzymes for the one-carbon cycle (the methylation cycle).base. The largest phenotype … is undermethylation. Read more here…

Changing the Face of Psychiatry

Walsh is convinced the use of psychiatric medication will eventually fade away as we learn more about normalizing brain function through nutritional interventions. “These powerful drugs … they do not normalize the brain. They cause an abnormal condition,” he warns. “They might correct depression or anxiety, but you wind up with something that’s not normal.”

The Walsh Research Institute is a public charity with no financial interests, and they are slowly but surely helping to change mainstream psychiatry. Walsh has given talks at the highest levels, including the Surgeon General’s office, the U.S. Senate and the National Institutes of Health (NIH). He’s also spoken at American Psychiatric Association (APA) annual meetings several times.

“The last time I went there, they finally listened to me … I was there about two and a half years ago. I gave an invited talk on depression. I basically explained to them they’re doing depression wrong. They actually listened to me. I showed them our huge chemistry database and explained that depression is a name given to at least five completely different disorders, each involving different symptoms and each involving different neurotransmitters that are malfunctioning.

Then I described each one of these biotypes and actually showed them that if they would simply do some inexpensive blood and urine testing, they could identify which people would be good candidates for selective serotonin reuptake inhibitors (SSRIs) or which ones would do better on benzodiazepine, but even more importantly, how they can correct it with nutrients.”

There were 17,000 psychiatrists at this meeting from all over the world, and Walsh was 1 of 4 speakers at a well-attended session. Afterward, there was tremendous demand for more information, which gives hope. Walsh also offers a training program for doctors. In the U.S., 45 psychiatrists went through the program last year. In all, 500 physicians and psychiatrists in 32 countries have taken his program so far.

Full Transcript at Dr Mercola’s Website

To learn more about Dr Walsh, visit www.WalshInstitute.org. There you can also purchase Walsh’s book, “Nutrient Power: Heal Your Biochemistry and Heal Your Brain.” Questions and information requests can be sent to Dana@WalshInstitute.org, or you can call (630) 506-5066.

“Our website has a resources section that recommends quality labs, compounding pharmacies and a list of doctors who we’ve trained, who are now able to do this kind of therapy,” Walsh says.

Copper Overload Linked to Autism, Schizophrenia and Postpartum Depression

Autism is particularly susceptible to copper overload and the effect on dopamine and norepinephrine  levels.

In his recent interview with Dr Mercola, Dr Walsh discusses copper, an important trace metal, that plays a distinct role in the synthesis of norepinephrine, a major neurotransmitter. Free copper impacts the levels of dopamine by causing this

Dopamine neurotransmitter is synthesized by humans and animals from L-Dopa in the kidneys and brain. It is also produced in plants.  This neurotransmitter is associated with the reward center, affecting desire, motivation craving for reward, associative learning (primarily positive reinforcement and classical conditioning), and positive emotions, particularly ones which involve pleasure as a core component (e.g., joy, euphoria and ecstasy).  It also manages aspects of motor control and in controlling the release of various hormones.

Norepinephrine is synthesized from the amino acid tyrosine by a series of enzymatic steps in the adrenal medulla and postganglionic neurons of the sympathetic nervous system. While the conversion of tyrosine to dopamine occurs predominantly in the cytoplasm, the conversion of dopamine to norepinephrine by dopamine β-monooxygenase occurs predominantly inside neurotransmitter vesicles. The metabolic pathway is:

Phenylalanine → Tyrosine → L-DOPA → Dopamine → Norepinephrine

Broadly speaking, the effect of norepinephrine on each target organ is via the symptathetic nervous system for the purpose of of making the body more conducive to active movement, often at a cost of increased energy use and increased wear and tear. Known as the “fight or flight” neurotransmitter it can be contrasted with the acetylcholine-mediated effects of the parasympathetic nervous system, which modifies most of the same organs into a state more conducive to rest, recovery, and digestion of food, and usually less costly in terms of energy expenditure.

Elevated levels of unbound, ‘free copper’ (copper overload) have a direct effect on the conversion of dopamine to norepinephrine. The consequence is lower levels of the reward center and increase levels of stress and anxiety. 

“It all has to do with an enzyme called metallothionein that is genetically expressed. Some people don’t have that system working,” Walsh explains. “These persons have copper overload, which we find virtually in every autistic patient, most patients with schizophrenia and almost everyone with postpartum depression.

That’s a recipe for very high norepinephrine — which means anxiety and depression — and low dopamine (a feel-good neurotransmitter), which is a hallmark of ADHD … a nasty combination.

We find the sociopaths innately have low copper levels. People who have undermethylation tend to have low normal copper levels … The good news for mental disorders is that there are more than 100 really important biochemicals in the body, but only a few dominate mental disorders.

If we had to do lab testing for 100 of them, it would be really difficult. If we had to adjust the levels of these and normalize 100 different factors, it would make life very difficult. But we found that by just focusing on maybe seven or eight nutrient factors, we could help 95 percent of the patients we see with nutrient therapy.”

How to Measure Your Zinc and Copper Status

Zinc experts typically agree that plasma zinc provides the most accurate measurement. The taste test has some minor value but is among the least reliable. To accurately measure copper, serum copper is the way to go, and most labs throughout the world provide good copper assays.

Walsh recommends doing a ceruloplasmin test at the same time, because then you can determine how much free radical copper you have, which gives you a good indication of your level of oxidative stress. A high sensitivity C-reactive protein (CRP) test would also be useful as a marker of inflammation.

“By the way, oxidative stress runs through every single mental disorder we see, without exception,” Walsh says. “Every one of them seems to have extraordinary oxidative stress — schizophrenia, bipolar disorder, a violent child or an autistic child.”

Unfortunately, our modern lifestyle strongly promotes oxidative stress, with processed foods, processed vegetable oils, excessive net carbs and excessive protein being some of the most potent factors. This kind of diet causes a reduction in ketones and a radical increase in reactive oxygen species and secondary free radicals.

Exposure to non-native electromagnetic fieldsglyphosate and other pesticides, fluoride-contaminated water and other toxic exposures only add to the problem. Typically, copper and ceruloplasmin levels tend to go hand in hand, being either high or low together. The ideal level for copper, with respect to mental health, is somewhere between 75 and 100 micrograms per deciliter (mcg/dL) in serum. The ideal amount of ceruloplasmin has to do with whatever your level of copper is.

Ideally, the percentage of copper in your ceruloplasmin should be around 85 to 90 percent. “It’s really great to do both simultaneously, because then you have a really good picture of not only the copper situation, but also the level of oxidative stress,” Walsh says.

Heavy Metals and the Autistic Brain

Walsh has tested 6,500 autistic patients. As a group, they have much higher toxic metal levels than their siblings or the general population. Walsh believes their toxic burden is likely due to an inborn predisposition that makes them more likely to accumulate toxins and/or vulnerable to the effects of toxins.

“Thousands of these parents, maybe more than half, told a very sad story of how they had a child who was developing normally, was beginning to speak and was singing and charming their grandparents. Then maybe the child got sick.

They took him to a pediatrician and the pediatrician — I’ve heard this story hundreds of times — said, ‘Oh, you’re behind on your shots. You’re behind on your vaccinations.’ They took a sick child and gave them multiple vaccinations, at that time, with thimerosal and mercury.

Hundreds of these families said that within a day or two, their child changed forever. Lost all speech, the personality changed, they became sick. They became intolerant to served foods. They were just very troubled little human beings.

When they went to specialists, eventually they wound up with the diagnosis of autism and were told that it was incurable and that there was no hope really for recovery. We’ve seen a lot of human misery just talking with these families. It’s just a shocking and terrible thing.”

Walsh suspects autistic children have an insufficiency of natural antioxidants such as glutathione and metallothionein, rendering them more vulnerable to the effects of environmental exposures, including vaccines and poor diet. It’s worth noting that 1 in 3 children diagnosed with autism does not have true autism caused by epigenetic variations.

Many of these children have a good chance of recovery, whereas classic Kanner autism is a permanent, life-long epigenetic condition (named after Leo Kanner, who discovered autism in the 1940s1), although some measure of improvement can be made even in these cases.

Metallothionein Promotion Nutrient Therapy for Autism

The fact that autistic children tend to have extraordinary copper and zinc imbalances means their metallothionein protein is not functioning. Metallothionein is required for homeostatic control of copper and zinc. Walsh has developed a metallothionein promotion nutrient therapy: a formulation of 22 nutrients known to enhance genetic expression and function of metallothionein. This protocol has been used on more than 2,000 autistic patients, with measurable improvements in outcome.

“The most important antioxidants in the brain are somewhat different than the rest of the body. I call them the three musketeers. It’s glutathione, metallothionein and selenium. It’s specific to the brain,” he explains.

Technically, selenium is not an antioxidant per se, but it does increase glutathione levels and enhances the function of metallothionein and, in the brain, glutathione and metallothionein work together. Glutathione is your first line of defense. The problem is, autistic children typically have a poor diet (it’s hard to get them to eat anything) and with the oxidative overload, they quickly run out of glutathione. When you run low on glutathione in your brain, your metallothionein level increases.

“Metallothionein doesn’t work unless you have oxidized glutathione. It’s a hand in glove situation. It’s the backup system for glutathione in the brain, and we know that without selenium, that whole system doesn’t work well,” Walsh explains.

I take selenium every day. It’s a trace mineral, so you don’t need much, up to about 200 mcg per day, and you definitely need to be mindful not to overdose. As noted by Walsh, of all the trace metals, selenium has the narrowest division between deficiency and overload, so you need to be careful when supplementing.

Zinc also needs to be normalized, as it is the No. 1 factor for enabling metallothionein to function and support glutathione. According to Walsh, for mental and physical health, you need a plasma zinc level between 90 and 130 mcg/dL. Many mental patients have a genetic weakness in zinc normalization; they’re born with zinc deficiency, and need far higher amounts than typical to maintain a healthy zinc level.

On Thimerosal

Walsh has also investigated the thimerosal issue, looking for evidence of mercury toxicity in the brains of autistic children. In fact, he was the first person to actually measure mercury in autistic brains.

He was able to receive brain tissue samples from Johns Hopkins, and using the Argonne facility called the Advanced Photon Source, he did over 1 million chemical analyses on brain tissue from autistic and non-autistic children. Every autistic child analyzed had received thimerosal-containing vaccinations.

However, no mercury could be found in the brain tissue. One explanation for this is that the tests were done years after the vaccinations. The half-life of mercury in the human body is 42 days. The half-life of ethyl or methyl mercury in the brain is 70 days.

“I think what it amounts to is that mercury is a terrible poison. It’s a terrible insult,” he says. “I think these vulnerable kids should never be exposed to it. However, it doesn’t stay in the body and it doesn’t do continuing damage. I think after a year or so, it has left the body, even though there are tens of thousands of families who are trying therapies that will take the mercury out of their child’s brain when it’s no longer there.”

Pyrrole Disorder and Depression

Among 10’s of thousands of individuals tested with depression, 15% turned out positive for pyrrole disorder known as kryptopyrroles. 

Biotype Pyrrole Depression

Patients who present with pyrrole disorder often are high in oxidative stress, suffer from severe mood swings and explosive anger, have extreme anxieties and fears, have poor short-term memory, and may have little or no dream recall. Depression strikes this subgroup usually because their kryptopyrroles are lost to their urine, which carries away the much needed B6 and Zinc.  Therefore these persons benefit greatly and often quickly from supplements of Vitamin B6 and P5P , both crucial to serotonin synthesis, and zinc supplementation. Pyrolurics also need more Omega 6 fats such as animal fat, borage or primrose oil  instead of Omega 3 fatty acids such as fish oils.  This inflammatory condition also benefits greatly from antioxidants such as Vitamin A, Vitamin D, Vitamin E, and Vitamin C.

Diagnosed with AD(H)D?  Anxiety?  Bipolar?  Depression?  It could be Pyrrole Disorder.  A high incidence of Pyrrole Disorder is found in individuals with depression, anxiety disorder, ODD, , bipolar disorder and AD(H)D.  Pyrrole Disorder is associated with elevated pyrroles in urine and severe deficiencies of zinc and pyridoxine (Vitamin B-6) throughout the body.  Ask yourself if you are experiencing symptoms of pyroluria. 

 
Testing for pyrrole disorder:  
Second Opinion Physician will arrange to have urine test kits sent to your home to determine your level of urinary pyrroles. 
 
Pyrrole Disorder Treatment:
 
You will be given a customized supplement plan that you may take to your local vitamin supplier or else use our recommended professional sources online. Second Opinion Physician provides product codes, dosages and times per day each supplement should be taken for your specific level of imbalance.
 
Temper Dysregulation Disorder 
 
Many children with severe temper tantrums, learning disabilities and oppositional defiant disorders actually suffer from pyrrole disorder. 
 

Symptoms of Pyrrole Disorder vary but may include:

                Urine

Elevated kryptopyrroles

Mauve colored urine

Digestive

Morning nausea

Tendency to delay or skip breakfast

Very dry skin

Affinity for spicy and salty foods

Body Features

Pale skin, inability to tan

White spots in nail beds

Sensitivity to bright lights

Sensitivity to loud noises

Poor wound healing

Joint pains

Premature graying of hair

Psoriasis

Delicate facial features

“Fruity” breath and/or body odor

Coarse eyebrow hair

Sretch marks (striae) on skin

Long arms, legs and fingers

Mood and Emotions

Extreme mood swings

Severe inner tension

Severe anxiety

Tendency to stay up very late

High irritability and temper

History of underachievement

Histrionic behavior

Severe depression

Fear of airplane travel, tornadoes, etc.

Obsessions with negative thoughts

Dreams and Memory

Little or no dream recall

Poor short-term memory

History of a reading disorder

Immunity and Inflammation

Autoimmune disorders

Severe oxidative stress

Poor growth

Delayed puberty

Spleen-area pain

Frequent infections

Abnormal EEG

Hormonal

Abnormal fat distribution

Abnormal or absent menstrual periods

Poor muscle development

·

Five Biotypes of Depression

The Five Biotypes of & Advanced Nutrient Therapies with William Walsh, PhD

Second Opinion Physician, David Epstein, D.O., is trained in the Walsh Protocol, developed by Dr. William J. Walsh, PhD, and committed to the natural treatment of depression, as well as other mood and behavioral disorders, thru the use of Nutrient Therapy.  It is estimated that 13.1 to 14.2 million American adults suffer from depression currently and that at least 32 million will similarly face this disease at some point in their lives.  However, the disease can be tricky to tackle for a number of reasons, not least of which are the grave misconceptions regarding depression which are upheld by mainstream psychiatry.  

Mainstream psychiatry typically regards depression as a “single entity with variations along a central theme”, according to Dr. Walsh.  It is also mostly assumed that those suffering from depression have low activity in the receptors in their brains responsible for the handling of serotonin, a monoamine neurotransmitter associated with feelings of “happiness and well-being”.  It is this central belief which informs most decisions as far as the majority of medications being used to treat depressive patients.  Most are prescribed SSRI medications which inhibit the reabsorption of serotonin into its originating receptor, thereby leaving more of the serotonin free to bind to postsynaptic receptors and to have positive effects, allegedly, on the entire organism.  However, after having evaluated 2,800 patients diagnosed with clinical depression, thru the lens of nutrient therapy, Dr. William Walsh is turning both of these centrally held misconceptions about depression and its treatment on their heads.  

By way of his evaluation and ongoing database studies, Dr. Walsh and his colleagues have identified five high-incidence depression biotypes.  These biotypes reference distinct and unique neurotransmitter & nutrient imbalances and symptoms, and therefore, according to Walsh, should be approached as 5 different disorders.  Additionally, he has made links between certain biotypes and the ineffectiveness of SSRI medications, even identifying some subgroups for whom SSRIs are actually dangerous.  

The biotype studies have given us great insight into these different depressive disorders, as well as a more workable look into what causes depression. Using this new revolutionary approach, Second Opinion Physician is able to direct patients towards lab tests which can identify the very nutrient & neurotransmitter imbalances triggering their particular depression, and can then provide recommendations for natural, highly effective, and individualized treatments.  This treatment will most often fall within the spectrum of about 6-8 different natural , along with dosage recommendations specific to the individual’s other biochemical status. 

A brief breakdown of each of the 5 Biotypes of Depression can be found below.

A note from our physician: Any one person will have variable combinations so the treatment must be individualized. I don’t recommend anyone trying to treat themselves based on this information unless a lab test is performed and a trained practitioner is coaching the individual. Follow link to learn more:

BIOTYPE 1 – Undermethylators – 38% of depression population

BIOTYPE 2 – Overmethylators  – or “Low-Folate Depressives” – 20% of depression population

BIOTYPE 3 – Pyrroluria or Pyrrole Depression – 15% of depression population

BIOTYPE 4 – Copper Overload or “High-Copper Depression” – 17% of depression population

95% of the patients in this subgroup are female.  Overly high copper levels can result in elevated norepinephrine and reduced dopamine in patients, high-anxiety and a tendency for panic, a high incidence of postpartum depression, estrogen intolerance, tinnitus, and extremely sensitive skin.  These persons are typically experiencing oxidative stress throughout their body as they have a limited ability to manage free radicals, such as heavy metals. Working to lower copper levels would be the nutrient therapy approach, but caution must be taken to not lower levels too quickly as it will temporarily worsen effects (due to copper leaving tissue and dumping into the blood or digestive tract).  Recommended supplements may include zinc, molybdenum, manganese and chromium (trace elements) and metalothionine producing amino acids. SSRIs are generally reported as ineffective for those suffering from High-Copper Depression.

BIOTYPE 5 – Toxic Metal Depression (5%)

These individuals have an excessive metal burden, such as lead toxicity.  They often exhibit severe oxidative stress, unrelenting depression, abdominal stress, a metallic taste in the mouth and bad breath, high levels of irritability or anger, and food sensitivities.  A gradual detox regimen might include supplements such as ALA, trace elements, metalothionine amino acids and antioxidants.  SSRIs are generally reported as ineffective for the Toxic Metal subgroup of patients struggling with depression.

Thanks to the dedicated work of Dr. William J. Walsh and other pioneers in the fields of nutrient therapy and , we now have more insight into some of the actual causes of depression, and can apply more targeted, individualized, effective, and safe treatments for patients.  Thru the recommendation of lab tests and subsequently the application of the various possibilities for nutrient and supplement based therapy, Second Opinion Physician can help patients finally break free from the painful and often debilitating struggle with depression, and other mood or behavioral disorders, to find relief and reclaim balance and health.d

Watch Video for more details:  Dr. William J. Walsh speaking to the American Nutrition Association about the 5 Biotypes of Depression and Advanced Nutrient Therapies

This is a simple summary followed by video of Dr Walsh explaining this in detail at the American Nutrition Association in 2014.

Any one person will have variable combinations so the treatment must be individualized. I don’t recommend anyone trying to treat themselves based on this information unless a lab test is performed and a trained practitioner is coaching the individual. There is usually about 6-8 different supplements and dosages recommended for the five  biotypes of depression, but it works something like this.