Among 10’s of thousands of individuals tested with depression, 15% turned out positive for pyrrole disorder known as kryptopyrroles.
Biotype #3 Pyrrole Depression
Patients who present with pyrrole disorder often are high in oxidative stress, suffer from severe mood swings and explosive anger, have extreme anxieties and fears, have poor short-term memory, and may have little or no dream recall. Depression strikes this subgroup usually because their kryptopyrroles are lost to their urine, which carries away the much needed B6 and Zinc. Therefore these persons benefit greatly and often quickly from supplements of Vitamin B6 and P5P , both crucial to serotonin synthesis, and zinc supplementation. Pyrolurics also need more Omega 6 fats such as animal fat, borage or primrose oil instead of Omega 3 fatty acids such as fish oils. This inflammatory condition also benefits greatly from antioxidants such as Vitamin A, Vitamin D, Vitamin E, and Vitamin C.
Diagnosed with AD(H)D? Anxiety? Bipolar? Depression? It could be Pyrrole Disorder. A high incidence of Pyrrole Disorder is found in individuals with depression, anxiety disorder, ODD, #schizophrenia, bipolar disorder and AD(H)D. Pyrrole Disorder is associated with elevated pyrroles in urine and severe deficiencies of zinc and pyridoxine (Vitamin B-6) throughout the body. Ask yourself if you are experiencing symptoms of pyroluria.
Testing for pyrrole disorder:
Second Opinion Physician will arrange to have urine test kits sent to your home to determine your level of urinary pyrroles.
Pyrrole Disorder Treatment:
You will be given a customized supplement plan that you may take to your local vitamin supplier or else use our recommended professional sources online. Second Opinion Physician provides product codes, dosages and times per day each supplement should be taken for your specific level of imbalance.
Temper Dysregulation Disorder
Many children with severe temper tantrums, learning disabilities and oppositional defiant disorders actually suffer from pyrrole disorder.
Symptoms of Pyrrole Disorder vary but may include:
Mauve colored urine
Tendency to delay or skip breakfast
Very dry skin
Affinity for spicy and salty foods
Pale skin, inability to tan
White spots in nail beds
Sensitivity to bright lights
Sensitivity to loud noises
Poor wound healing
Premature graying of hair
Delicate facial features
“Fruity” breath and/or body odor
Coarse eyebrow hair
Sretch marks (striae) on skin
Long arms, legs and fingers
Mood and Emotions
Extreme mood swings
Severe inner tension
Tendency to stay up very late
High irritability and temper
History of underachievement
Fear of airplane travel, tornadoes, etc.
Obsessions with negative thoughts
Dreams and Memory
Little or no dream recall
Poor short-term memory
History of a reading disorder
Immunity and Inflammation
Severe oxidative stress
Abnormal fat distribution
Abnormal or absent menstrual periods
Poor muscle development
The Five Biotypes of #depression & Advanced Nutrient Therapies with William Walsh, PhD
Second Opinion Physician, David Epstein, D.O., is trained in the Walsh Protocol, developed by Dr. William J. Walsh, PhD, and committed to the natural treatment of depression, as well as other mood and behavioral disorders, thru the use of Nutrient Therapy. It is estimated that 13.1 to 14.2 million American adults suffer from depression currently and that at least 32 million will similarly face this disease at some point in their lives. However, the disease can be tricky to tackle for a number of reasons, not least of which are the grave misconceptions regarding depression which are upheld by mainstream psychiatry.
Mainstream psychiatry typically regards depression as a “single entity with variations along a central theme”, according to Dr. Walsh. It is also mostly assumed that those suffering from depression have low activity in the receptors in their brains responsible for the handling of serotonin, a monoamine neurotransmitter associated with feelings of “happiness and well-being”. It is this central belief which informs most decisions as far as the majority of medications being used to treat depressive patients. Most are prescribed SSRI medications which inhibit the reabsorption of serotonin into its originating receptor, thereby leaving more of the serotonin free to bind to postsynaptic receptors and to have positive effects, allegedly, on the entire organism. However, after having evaluated 2,800 patients diagnosed with clinical depression, thru the lens of nutrient therapy, Dr. William Walsh is turning both of these centrally held misconceptions about depression and its treatment on their heads.
By way of his evaluation and ongoing database studies, Dr. Walsh and his colleagues have identified five high-incidence depression biotypes. These biotypes reference distinct and unique neurotransmitter & nutrient imbalances and symptoms, and therefore, according to Walsh, should be approached as 5 different disorders. Additionally, he has made links between certain biotypes and the ineffectiveness of SSRI medications, even identifying some subgroups for whom SSRIs are actually dangerous.
The biotype studies have given us great insight into these different depressive disorders, as well as a more workable look into what causes depression. Using this new revolutionary approach, Second Opinion Physician is able to direct patients towards lab tests which can identify the very nutrient & neurotransmitter imbalances triggering their particular depression, and can then provide recommendations for natural, highly effective, and individualized treatments. This treatment will most often fall within the spectrum of about 6-8 different natural #supplements, along with dosage recommendations specific to the individual’s other biochemical status.
A brief breakdown of each of the 5 Biotypes of Depression can be found below.
A note from our physician: Any one person will have variable combinations so the treatment must be individualized. I don’t recommend anyone trying to treat themselves based on this information unless a lab test is performed and a trained practitioner is coaching the individual. Follow link to learn more:
95% of the patients in this subgroup are female. Overly high copper levels can result in elevated norepinephrine and reduced dopamine in patients, high-anxiety and a tendency for panic, a high incidence of postpartum depression, estrogen intolerance, tinnitus, and extremely sensitive skin. These persons are typically experiencing oxidative stress throughout their body as they have a limited ability to manage free radicals, such as heavy metals. Working to lower copper levels would be the nutrient therapy approach, but caution must be taken to not lower levels too quickly as it will temporarily worsen effects (due to copper leaving tissue and dumping into the blood or digestive tract). Recommended supplements may include zinc, molybdenum, manganese and chromium (trace elements) and metalothionine producing amino acids. SSRIs are generally reported as ineffective for those suffering from High-Copper Depression.
BIOTYPE 5 – Toxic Metal Depression (5%)
These individuals have an excessive metal burden, such as lead toxicity. They often exhibit severe oxidative stress, unrelenting depression, abdominal stress, a metallic taste in the mouth and bad breath, high levels of irritability or anger, and food sensitivities. A gradual detox regimen might include supplements such as ALA, trace elements, metalothionine amino acids and antioxidants. SSRIs are generally reported as ineffective for the Toxic Metal subgroup of patients struggling with depression.
Thanks to the dedicated work of Dr. William J. Walsh and other pioneers in the fields of nutrient therapy and #epigenetics, we now have more insight into some of the actual causes of depression, and can apply more targeted, individualized, effective, and safe treatments for patients. Thru the recommendation of lab tests and subsequently the application of the various possibilities for nutrient and supplement based therapy, Second Opinion Physician can help patients finally break free from the painful and often debilitating struggle with depression, and other mood or behavioral disorders, to find relief and reclaim balance and health.d
Watch Video for more details: Dr. William J. Walsh speaking to the American Nutrition Association about the 5 Biotypes of Depression and Advanced Nutrient Therapies
This is a simple summary followed by video of Dr Walsh explaining this in detail at the American Nutrition Association in 2014.
Any one person will have variable combinations so the treatment must be individualized. I don’t recommend anyone trying to treat themselves based on this information unless a lab test is performed and a trained practitioner is coaching the individual. There is usually about 6-8 different supplements and dosages recommended for the five biotypes of depression, but it works something like this.
- 5 Biotypes of Depression
- ASD Autistic Spectrum
- Copper and Emotions
- Histamine and Methylation
- Medical Marijuana
- Medications for Depression
- Metals and the Mind
- Mood and Behavior Disorders
- Nutrition and Depression
- Walsh Podcasts and Videos
- Walsh Protocol