How apple cider vinegar may assist overmethylators

This publication suggests that acetate, derived from acetic acid, may assist the brain and other organs in reducing inflammation. That it does so specifically by acetylating DNA histones, explains the effectiveness of products such as organic apple cider vinegar in managing overmethylators.

Overmethylators, who may be identified by a histamine blood test, would benefit because acetyl-CoA competes with methyl compounds at the DNA histone. Whichever molecule binds to the histones determines if the cell turns to the slow mode or fast mode. In other words, histone and methylation control the activation of the cell and the product of their DNA transcription to produce proteins.

In summary, apple cider vinegar’s affect on histones could be very good for overmethylators. And consequently it may not be so good for undermethylators. Inadequately nourished or supplemented overmethylators have a tendency manifest symptoms of verbosity, paranoia, phobias and at the further end of the scale auditory and delusional schizophrenia. Dr William Walsh PhD believes that as many as 46% of persons with schizophrenia are overmethylators.

 

Acetate supplementation increases brain histone acetylation and inhibits histone deacetylase activity and expression.

Soliman ML1, Rosenberger TA.

Author information

Abstract

Acetate supplementation increases brain, heart, and liver acetyl-CoA levels and reduces lipopolysaccharide-induced neuroinflammation. Because intracellular acetyl-CoA can be used to alter histone acetylation-state, using Western blot analysis, we measured the temporal effect that acetate supplementation had on brain and liver histone acetylation following a single oral dose of glyceryl triacetate (6 g/kg). In parallel experiments, we measured the effect that acetate supplementation had on histone deacetylase (HDAC) and histone acetyltransferase (HAT) enzymic activities and the expression levels of HDAC class I and II enzymes using Western blot analysis. We found that acetate supplementation increased the acetylation-state of brain histone H4 at lysine 8 at 2 and 4 h, histone H4 at lysine 16 at 4 and 24 h, and histone H3 at lysine 9 at 4 h following treatment. No changes in other forms of brain or liver H3 and H4 acetylation-state were found at any post-treatment times measured. Enzymic HAT and HDAC assays on brain extracts showed that acetate supplementation had no effect on HAT activity, but significantly inhibited by 2-fold HDAC activity at 2 and 4 h post-treatment. Western blot analysis demonstrated that HDAC 2 levels were decreased at 4 h following treatment. Based on these results, we conclude that acetyl-CoA derived from acetate supplementation increases brain histone acetylation-state by reducing HDAC activity and expression.

william.walsh.podcast

Methylation and Epigenetics – William Walsh PhD Podcast

Methylation Overview:

New discoveries in the field of epigenetics have led to effective advanced nutrient therapies for children and adults challenged by brain disorders, such as autism, Alzheimer’s, depression, bipolar, schizoaffective disorders, and ADHD/ADD. A Walsh panel can determine a clients’ methylation status, and thus a treatment based on their biochemical individuality. Dr. David Epstein, D.O., offers full assessments and specific recommendations to clients according to the Walsh protocol. Second Opinion Physician is a holistic telemedicine practice, specializing in nutrient therapies developed by Dr William J Walsh and the Walsh Research Institute.

Podcast below provide by:

The CoreBrain Journal Walsh Molecular Series: 

Dr Walsh provides a more detailed description of the significance of methylation and epigenetics and the consequence of undermethylation or overmethylation on mood and mental function. CLICK ARROW BELOW TO BEGIN:

 

About Dr Walsh               

William J. Walsh, PhD, FACN, president of the nonprofit Walsh Research Institute, is an internationally recognized expert in the field of nutritional medicine and a key scientist paving the way for nutrient-based psychiatry and nutritional medicine.  Over the past 30 years, Dr. Walsh has developed biochemical treatments for patients diagnosed with behavioral disorders, attention deficit (hyperactivity) disorder, autism, clinical depression, anxiety, bipolar disorders, schizophrenia, and Alzheimer’s disease that are used by doctors throughout the world.

His book, Nutrient Power: Heal Your Biochemistry and Heal Your Brain [updated May 2014], describes specific findings for his evidence-based nutrient therapy system.

Dr. Walsh’s noted accomplishments include:  (a) groundbreaking studies reporting reduced violent behavior following nutrient therapy, (b) the 1999 discovery of undermethylation and copper/zinc imbalances [Coming: CBJ/034] in autism, (c) the 2000 finding of metallothionein protein depletion in autism, (d) the 2007 published study linking copper overload and post-partum depression, (e) the identification of five biochemical subtypes of clinical depression, (f) the 2011 development of the Walsh Theory of Schizophrenia [Coming: CBJ/042], and (g) the direction of the Beethoven Research Project that revealed that the composer suffered from severe lead poisoning.

His internationally acclaimed presentations, including for the American Psychiatric Association, affirm his important contributions to both functional and traditional medical groups.

Clinical Experience

After earning degrees from Notre Dame and the University of Michigan, Dr. Walsh received a PhD in chemical engineering from Iowa State University.  While working at Argonne National Laboratory in the 1970s, Dr. Walsh organized a prison volunteer program that led to studies of prisoners and ex-offenders researching the causes of their violent behavior.  The collaboration with renowned (late) Carl C. Pfeiffer, MD, PhD, a pioneer in the field of nutritional research therapy, led Dr. Walsh to the development of individualized nutrient protocols to normalize body chemistry and brain chemistry. Dr. Walsh went on to study more than 30,000 patients with mental disorders acquiring an unparalleled database of more than 3 million chemical assays during his clinical and research work.

NB: Dr. Walsh has conducted chemical analysis of more than 25 serial killers and mass murderers, including Charles Manson, Richard Speck, James Oliver Huberty, Patrick Sherrill and Arthur Shawcross.  He has assisted medical examiners, coroners, Scotland Yard, and the FBI in these forensics studies. He has designed nutritional programs for Olympic athletes, NBA players, major league baseball players, a heavyweight boxing champion, PGA and LPGA golfers, and others.

 

Autistic Children Natural Therapies

The Epigenetic Theory of Autism

 

The following was taken from an intereview with Dr Walsh by Dan E Burns and his excellent website, the Age of Autism. If you like this article, please visit his website.

Autism: Tornado in the Brain

By William Walsh and Dan E. Burns

“It’s becoming quite clear to more and more of us that autism is not genetic, but epigenetic.” So says William J. Walsh, who received a Ph.D. in chemical engineering from Iowa State University and is an expert in nutritional medicine. In the 1970s, he collaborated with the renowned Dr. Carl Pfeiffer, a pioneer in schizophrenia research, and went on to develop nutrient protocols to normalize brain chemistry in patients with behavioral and personality disorders, schizophrenia, and autism. Walsh’s new book, Nutrient Power, is subtitled Heal Your Biochemistry and Heal Your Brain.

I asked Bill what has happened in autism research since the late 1980s when he became associated with Dr. Rimland, founder of the Autism Research Institute. Here’s what he told me.

BILL: “When I first connected with Bernie, a wonderful inspiring man, he realized that I’d seen more autistic patients than anybody in the world, eventually six thousand five hundred. More importantly, I had the world’s biggest chemistry database for autism. I’d already organized a prison volunteer program to study the biology of prisoners and ex-offenders, researching the causes of their violent behavior. And the first thing Bernie and I realized was that autistic children – ASD spectrum kids – have far more severe chemistry, lab results farther outside the normal range, than criminals.

“Bernie asked me to come to some of his think tanks and give information. No one was surprised when I reported that ASD kids had B6 deficiency and elevated toxic metals, especially mercury, cadmium, and lead, plus high copper and low zinc. The surprise was that more than 95% of kids who had autism were undermethylated. Following that think tank, Jon Pangborn launched a study of how disruptions in the methylation cycle are consistent with ASD symptoms. Eminent methylation scientists Jill James and Richard Deth took up the challenge. We now know that undermethylation is a distinctive feature of ASD.”

Dan: Why did you develop the Epigenetic Theory?

BILL: “In the history of science, progress has often been hastened by the development of theories that attempt to explain the mechanisms of poorly understood phenomena. Then, over time, as new information comes in, the model can be honed and improved. We needed a new theory to account for the effect of environmental toxins on gene expression. That’s why I developed the epigenetic theory of autism.”

DAN: What’s the difference between genetics and epigenetics? My understanding is that genetic theories of autism have not been very helpful to date.

BILL: “That’s right. Genetic therapies – trying to change DNA that’s gone awry in kids, with Down Syndrome, for example – have been a washout. They haven’t led to much of anything. But the early research on altering epigenetic deviations has been really promising. And I think that’s the hope for the future.”

DAN: So what is epigenetics?

“Epigenetics is the natural process of gene regulation that is established in the early days of gestation in the womb. A severe environmental insult later in life can either turn off a necessary gene or turn on a damaging gene, resulting in a disorder that can persist for years.

“We know that autism runs in families but violates classical laws of genetics. We know that in identical twins, if one of them develops autism, it’s more than sixty percent likely that the other will too. However, it’s not a hundred percent; so it’s not the DNA, not the genome. That means that environmental insults must be involved.”

DAN: How can environmental insults lead to autism without altering the genome?

BILL: “A gene has only one job, and that’s to make a protein. We have identical DNA and identical genes – the same cookbook – in every cell of our body, but every tissue in our body needs a different combination of proteins. How to make that happen? Methyl groups, which are basically groups of carbon atoms with some hydrogen attached, act like bookmarks. They tell our metabolism where to start reading the cookbook and where to stop. Methyl groups attach to certain parts of DNA to regulate whether a gene is turned on or turned off. So they program the DNA and determine which proteins are expressed in each tissue.”

DAN: It reminds me of an old-fashioned player piano. The piano is your DNA, and the scroll is your epigenome. The holes in the scroll determine which string is played or “expressed,” so you can play “Johnny B. Goode” or a Bach cantata by changing the scrolls.

BILL: “Yes. You can program the tune – the cell – without changing the DNA.”

DAN: But how does this epigenetic theory explain children who appear to be normal at birth but regress in their second year? Have you seen that happen?

BILL: “I’ve seen probably five thousand children who had a normal beginning in life, and around age 18 to 24 months had the very nasty sudden regression when autism onset came. I believe that altered epigenetics in the womb causes weakened protection against oxidative stress. And it’s pretty clear that somewhere between conception and age three, there was an environmental insult that just overwhelmed their anti-oxidant protectors and shuffled the epigenetic bookmarks, resulting in deviant gene expression. The trigger may be prenatal, postnatal, or cumulative (both). Here’s my epigenetic model in a nutshell:

  1. Undermethylation in the womb causes overexpression of several genes, weakened protection against oxidative stress, and increased vulnerability to environmental insults.
  2. Environmental insults, which can include mercury, lead, cadmium, viruses, or other sources, reach a tipping point and overwhelm natural antioxidant protectors, reshuffling epigenetic bookmarks and altering gene expression.
  3. Altered gene expression results in abnormal brain development, a tendency for serious brain inflammation, and physical problems including weakened immunity, sensitivity to toxins and certain foods, tendency to seizures, and poor behavior control. The Epigenetic Model of Autism is explained in more detail on pages 110-111 of my book Nutrient Power.”

DAN: In your AutismOne presentation, you said that mercury does its damage in 30 seconds. That would make it like a tornado, sweeping in and out of Moore, Oklahoma, and leaving devastation behind. Am I remembering that right? Please explain.

BILL: “When mercury enters the brain, it quickly undergoes chemical reaction with substances in the brain. A large amount of mercury can cause great damage, especially in the developing brain of a young child. This is a leading suspect in the onset of regressive autism. However, in most humans, the half-life of mercury in the brain is about 70 days, and the reacted mercury may have become inert before departing the scene. Experimental evidence indicates that mercury levels in brains of the older autistic children we looked at, ages 5-11, were not seriously high. A mercury insult may well have triggered autism in many children, but it appears this early mercury has left the body and cannot cause continuing harm. The problem is that epigenetic changes survive cell division, so the autism conditions can persist a lifetime, even after the mercury is gone. After a tornado, there may be great destruction but the problem is no longer the tornado but the damage that it caused. The same may be true for environmental insults like mercury.”

DAN: Shouldn’t our children get better? Aren’t old, damaged brain cells replaced, eventually, by new ones, as mercury leaves the brain?

BILL: “You’re asking about the greatest mystery of autism – Why in stubborn cases doesn’t it go away after onset, despite the multitude of aggressive treatments that have been tried? The answer appears to be epigenetics – an environmental insult has altered gene regulation and set up misleading detour signs along the developmental pathways. The good news is that biochemical therapies and other interventions can either (a) adjust gene expression or (b) overcome the effect of altered gene expression. For example an epigenetic tendency for high oxidative stress can be effectively treated using antioxidant supplements.

“Unfortunately, autism is a developmental disorder and as the child matures, the effects of altered gene expression are cast in physiology. Autism brains are structurally different from neurotypical brains. The differences includes narrowed minicolumns in the brain’s cortex, altered connectivity between different brain areas, a reduced number of synapses, and certain brain areas that have never completed the maturation process. It’s conceivable that the developmental detour signs could someday be removed. But fixing the autism brain requires a lot more than replacing damaged brain cells. Fortunately, the brain is very plastic and brain-directed therapies have great promise.”

DAN: Can epigenetic variations be passed on?

BILL: “Yes, and that was something that was a surprise. Because we’ve known that when conception begins, the epigenetic markers from the mother and the father are supposed to be erased, and you get a new start. But now there’s clear evidence that there’s something called ‘Transgenerational Epigenetic Inheritance’ or TEI transference. If a father has an exposure to mercury, and that mercury changes his gene expression, which can happen, the next two generations of children are likely to have the same problem. In other words, epigenetics can pass from father to son. I like to use a quote from Deuteronomy: ‘The sins of the father will be visited upon the son.’”

DAN: What about the mother?

BILL: “The mothers are even more important if you look at the things that can cause epigenetic errors. One of them is an insufficient level of folates or folic acid in a pregnant woman. Another would be toxic metals such as mercury, lead or cadmium. We know that they can cause epigenetic errors. Under-methylation in the womb is a major factor in brain development and epigenetic errors. And those errors are heritable.”

DAN: Since lead has been removed from gasoline and from paint, and since mercury has been mostly phased out of mandated childhood vaccines (but not flu shots) beginning in the year 2000, shouldn’t autism rates be going down, not up? Why doesn’t the incidence of autism decline?

BILL: “Starting in 2005, about the time we would expect a dramatic decrease in autism incidence because of the phase-out, my colleagues and I noticed a huge increase in patients diagnosed with autism whose biochemical profiles did not match our typical chemical profile of ASD kids. Were they misdiagnosed? By the standards we were using, yes. We had to exclude them from the research studies. Clearly something new was going on here. However, we continued to see large numbers of children with severe autism throughout the period. Like many others, I was disappointed to learn that the removal of mercury from USA childhood vaccines failed to result in a dramatic decline in autism incidence.”

DAN: So what is driving the epidemic now?

BILL: “There are three points to keep in mind.

“First, as Dan Olmsted points out, the increased uptake of mercury-containing prenatal flu shots given to pregnant women appears to layer in just as the other mercury-containing shots were phasing out. Many epigenetic deviations occur around day 20, before most women know they’re pregnant. I think that’s a very serious issue.

“Second, altered epigenetics due to undermethylation persists across generations, and most great athletes, doctors, lawyers, and CEOs are undermethylated. Put undermethylated men and women together, which is inevitable in our increasingly stratified society, and that’s probably another reason why the epidemic persists.

“Third, toxic metals and viruses are not the only risk factors. Dozens of other genotoxins could potentially trigger autism in a predisposed child. Kathy Blanco has listed at least twenty five. Many of these have not been explored in depth. We need to keep an open mind and not let what we know blind us to what we don’t know. Emotion is the enemy of science and logical thought.”

DAN: Where does your epigenetic theory of autism lead us? What is your vision of the future?

BILL: “Not too far in the future autism can be prevented. In some unknown year, at some future time, newborn babies will be tested for not just their genetics, but their epigenetics, to determine what genes are turned on and off properly or improperly. I think there will be therapies to fix that early on, based on recent advances in reversing deviant epigenetic bookmarks in cancer. Epigenetic therapies will probably be the most effective therapies in the future for children. These therapies don’t really exist yet, but they’re coming.”

Dan E. Burns, Ph.D., is the father of a 25-year-old son on the autism spectrum and the author of Saving Ben: A Father’s Story of Autism. Through his new dba, Appleseed Ventures, Dan empowers parents to organize communities where their adult ASD children and friends can live, work, play, and heal.

William J. Walsh  Ph.D., is an internationally recognized expert in the field of nutritional medicine. He is president of the non-profit Walsh Research Institute in Illinois and conducts physician training programs in advanced biochemical/nutrient therapies in Australia, Norway and other countries. His book, Nutrient Power (Skyhorse Publishing), which describes an evidence-based nutrient therapy system, was recently published. He has authored numerous peer-reviewed journal articles and scientific reports, as well as been granted five patents. He has presented his experimental research at the American Psychiatric Association, the U.S. Senate, and the National Institutes of Mental Health. After earning degrees from Notre Dame and the University of Michigan, Dr. Walsh received a Ph.D. in chemical engineering from Iowa State University. While working at Argonne National Laboratory in the 1970s, Dr. Walsh organized a prison volunteer program that led to studies of prisoners and ex-offenders researching the causes of their violent behavior. A collaboration with Carl C. Pfeiffer, M.D., Ph.D., a pioneer in the field of nutritional research therapy, led Dr. Walsh to the development of individualized nutrient protocols to normalize body chemistry and brain chemistry. Over the next 30 years, Dr. Walsh developed biochemical treatments for patients with behavioral disorders, attention deficit hyperactivity disorder, autism, depression, anxiety disorders, schizophrenia and Alzheimer’s disease that are used by doctors throughout the world. Dr. Walsh has studied more than 25,000 patients with mental disorders. His accomplishments include (a) groundbreaking studies reporting reduced violent behavior following nutrient therapy, (b) the 1999 discovery of undermethylation and copper/zinc imbalances in autism, (c) the 2000 finding of metallothionein protein depletion in autism, (d) the 2007 published study linking copper overload and post-partum depression, (e) the identification of five biochemical subtypes of clinical depression, (f) the 2011 development of the Walsh Theory of Schizophrenia, and (g) the direction of the Beethoven Research Project that revealed that the composer suffered from severe lead poisoning. Dr. Walsh has conducted chemical analysis of more than 25 serial killers and mass murderers, including Charles Manson, Richard Speck, James Oliver Huberty, Patrick Sherrill and Arthur Shawcross. He has assisted medical examiners, coroners, Scotland Yard, and the FBI in these forensics studies. He has designed nutritional programs for Olympic athletes, NBA players, major league baseball players, a heavyweight boxing champion, PGA and LPGA golfers, and others. Walsh Research Institute’s current research includes studies of autism brain tissues, the role of epigenetics in mental health, oxidative stress in disease conditions, and underlying causes of bipolar disorder.

natural.remedies.mood.disorders

Natural Remedies for Mood Disorders

Pioneers in the field of Nutrient Therapy, such as Carl Pfeiffer, MD, PhD and William J. Walsh, PhD, President of the Walsh Research Institute, have found abnormalities in and elevated or reduced levels of histamines in the body to be central to many different behavioral or mood disorders, such as bipolar disorder, depression, anxiety, panic disorders, and even classical paranoid .  The effects of being over or under methylated or of having abnormalities in histamine levels are vast and often debilitating… but the good news is that there exists completely safe and natural remedies for these imbalances!  And the power, speed, and efficacy of these natural remedies can be a source of great hope and relief for sufferers of mood disorders, including depression, anxiety, and other upsetting conditions that are not uncommon in an increasingly toxic and often stressful modern way-of-life.

BIOTYPE 1 – Undermethylators (38% of depression population):

Some of the common characteristics of this depressive group are: OCD tendencies, calm exterior but high inner tension, competitive, perfectionistic, addictive tendencies, and high libido.  Undermethylators may be benefited by SSRI medications, but often with side-effects.  The Nutrient Therapy approach would most likely include the addition of methionine or SAMe. These amino acids contribute a methyl compound and increase total serotonin production.  Other important supplements include inositol, B6, calcium, magnesium and vitamin C.

Folic acid is absolutely not recommended for these types.

BIOTYPE 2 – Overmethylators (or “Low-Folate Depressives”) (20% of depressed population):

Some of the commonly recurring characteristics within this population are: high anxiety, panic, noncompetitive in sports or games, food/chemical sensitivities, high musical or artistic ability, underachievement, sleep disorders, and low libido.  This subtype tends to do poorly with methylation and in fact do very poorly with SSRI antidepressants. This is because they have plenty of serotonin, but they lack B12 and Folic Acid. Likewise, SAMe and methionine are not recommended.  An effective nutrient therapy would seek to enhance acetylation and suppress methylation for these patients, folate and niacinamide being excellent supplements for this.

Excellent Podcast Below Featuring William Walsh PhD on Bulletproof Radio Discussing Methylation

One-carbon (methyl) groups are integral to the synthesis of neurotransmitters, genetic expression, metabolism, and other crucial biochemical reactions.  Methylation, also referred to as the methyl/folate ratio, turns cells on and off through histone bodies which are connected to the .  DNA is responsible for the production of proteins which can express in the form of enzymes, hormones, inflammatory cells, neurotransmitters, and more.  Methylation affects anything that is produced by the differentiated cells of the body.  As far as brain function is concerned, methylation is a major player in the synthesis of serotonin, dopamine, and norepinephrine, three neurotransmitters whose proper balancing and healthy levels are essential for the maximized functioning of our brains and for the maintenance of a healthy emotional life.

In overmethylated patients there tends to be an abundance of serotonin, dopamine, and norepinephrine whereas undermethylated patients tend to be depleted in these essential neurotransmitters.  Within the realm of behavioral disorders, what is crucial is the enzyme which is responsible for returning serotonin to the originally releasing neurotransmitter (a process referred to as reuptake).

  • When methylation is high (“”), the enzyme levels that return serotonin back to the releasing neuron are low and there is increased serotonin activity.  When methylation is low (“”), the enzyme levels will be in excess and the serotonin activity will be low.
  • Additionally, overmethylation inhibits expression of the genes, of each cell in the body. It does this by causing a folding of the DNA structures. Undermethylation will cause DNA to unfold, making it more expressive.  Folding of the DNA diminishes the activity of that DNA which are responsible for the daily producing of critical hormones, enzymes and other types of proteins etc. All of these factors contribute to conditions ranging from autism to alzheimers, depression and anxiety. Understanding this new science gives us an opportunity to more successfully utilize natural remedies for mood disorders and healthy brain activity in general.

More than two decades ago, Dr. Pfeiffer studied the metabolism of over 20,000 patients suffering from schizophrenia and kept running into the phenomenon of severely deficient levels of histamine in these patients, later referring to this low histamine syndrome as “histapenia”.  Histapenia was found to be common in his classical paranoid schizophrenic patients, as well as those suffering from anxiety and panic disorders.  The histamine deficiency also coincided with nutrient deficiencies, specifically folic and and/or B12, and with an overload of copper.  Based on these findings, Dr. Pfeiffer enacted an aggressive therapy regime using B12, B3, and folic acid for these patients… and had tremendous success!  The patients experienced dramatic improvements, and Dr. Pfeiffer attributed the success to the elevation of histamine levels.  Ensuing studies have pointed to the role of the methyl/folate ratio and its normalization as being critical to these favorable outcomes.

  • Elevated histamine indicates undermethylation, and there are symptoms which may point to this being the case for an individual, for example: seasonal allergies, obsessive-compulsive tendencies, being strong-willed, perfectionism, and high-libido, just to name a few.
  • Some conditions associated with undermethylation are OCD obsessive compulsive disorder, trichotillomania, oppositional-defiant disorder, competitiveness, bulimia, anorexia, impulsivity (gambling/shopping disorders, etc), depression, schizoaffective disorder, and delusions.

On the other hand, overmethylated persons typically suffer from food/chemical sensitivities, dry eyes, and a severe intolerance to SSRI medications (such as Prozac, Celexa, Lexapro, Luvox, Paxil, Zoloft, etc), and have strong association with anxiety and panic disorders, low motivation, paranoid schizophrenia, hyperactivity, anxious depression, learning disabilities, and even hallucinations.

At Second Opinion Physician we request labs to be done for all patients (appropriate to the information gathered at initial consultation) in order to assess nutrient levels, and which includes testing for methylation levels, so that we might then effectively prescribe natural remedies for mood disorders.

  • If a patient is found to be overmethylated we typically treat with folic acid and B12, plus a focus on dietary considerations (for example, perhaps recommending an increase in animal skin, cartilage, and gelatin consumption in order to provide B vitamins and proteins which naturally counter excess methylation).  B12 and folic acid therapies can noticeably slow down methylation symptoms within 2 weeks to 2 months.
  • If methylation is low, we strive to increase serotonin production naturally, with supplements/nutrients such as B6 and Zinc and may recommend adding methionine to the patient’s diet, which comes naturally from muscle meats.  We may also recommend the addition of SAMe, which is a fast-acting and more readily available methylator.  Patients may see major effects with methionine in about 1-3 months, and even more quickly with SAMe treatment.

Methylation and histamine-level balancing is just one example of the nutrient-based approach to health taken by Second Opinion Physician.  By using natural remedies to balance brain chemistry and improve methylation status we can tackle even the most tenacious mood disorders, behavioral disorders, combat anxiety, and treat depression naturally to create more overall health and emotional balance for otherwise suffering individuals.

William Walsh Protocol Practitioners

Listen to William Walsh PhD Podcast with Bulletproof Radio:

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What is epigenetics?

Epigenetics is the at the core of what I practice with SOP, particularly when working with balancing brain chemistry through nutritional supplemenation.

What is epigenetics? Simplified it is a modification of the expression of DNA. No change in DNA, just in how the proteins are expressing themselves.

This page from Zymo Research simplifies the explanation of “what is epigenetics?”

Epigenetic mechanisms can be just as important to biological events as genetic mechanisms, and can also result in stable and heritable changes. However, the big difference between genetic and epigenetic regulation is that epigenetic mechanisms do not involve a change to the DNA sequence, whereas genetic mechanisms involve the primary DNA sequence and changes or mutations to this sequence.  Epigenetic regulation involves the modification of DNA and the proteins associated with DNA, which results in changes to the conformation of DNA and accessibility of other factors to DNA, without a change to the sequence of the DNA.

The importance of nature versus nurture has long been disputed. It cannot be denied that environment greatly influences how a child grows and develops, nor can it be denied that our DNA is the blueprint that makes us who we are. Epigenetics merges these two seemingly contradictory lines of thought to explain how environmental factors cause physical modifications to DNA and its associated structures, which result in altered functions.

The most commonly known epigenetic modification is DNA methylation. Although many technologies have been developed in the past to characterize genomic DNA methylation, none of them has been able to efficiently determine DNA methylation patterns on a genomic scale. Until now.

The below is a quote from Dr. Kristi B. Adamo, PhD., Research Scientist and CIHR New Investigator, Director of HALO Research Laboratory at Children’s Hospital of Eastern Ontario (CHEO) Research Institute, 401 Smyth Rd. Ottawa ON K1H 8L1.

Relationship Between Obese Moms and Kids †epigenetics home environment or both

Nalin Siriwardhana, Ph.D., interviewed 

Epigenetic regulation is a natural process that is required to ‘turn-on’ or ‘turn-off’ genes in certain systems or at specific points in time that contribute to typical development throughout life. However, different environmental conditions or disruptions can change the expected epigenetic patterns and thus lead to increased susceptibility to disease later on. In other words, epigenetic modifications can also be acquired over time, a simple example of which is gene-environment interaction. We know that identical twins have the same genetics but their epigenetic patterns in later life can be markedly different. This is because each twin may have been exposed to very different environments which have impacted their epigenetics markings and thus you can see differences when observing twins who grew up in different environments (this includes their lifestyles).