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How apple cider vinegar may assist overmethylators

This publication suggests that acetate, derived from acetic acid, may assist the brain and other organs in reducing inflammation. That it does so specifically by acetylating DNA histones, explains the effectiveness of products such as organic apple cider vinegar in managing overmethylators.

Overmethylators, who may be identified by a histamine blood test, would benefit because acetyl-CoA competes with methyl compounds at the DNA histone. Whichever molecule binds to the histones determines if the cell turns to the slow mode or fast mode. In other words, histone and methylation control the activation of the cell and the product of their DNA transcription to produce proteins.

In summary, apple cider vinegar’s affect on histones could be very good for overmethylators. And consequently it may not be so good for undermethylators. Inadequately nourished or supplemented overmethylators have a tendency manifest symptoms of verbosity, paranoia, phobias and at the further end of the scale auditory and delusional schizophrenia. Dr William Walsh PhD believes that as many as 46% of persons with schizophrenia are overmethylators.

 

Acetate supplementation increases brain histone acetylation and inhibits histone deacetylase activity and expression.

Soliman ML1, Rosenberger TA.

Author information

Abstract

Acetate supplementation increases brain, heart, and liver acetyl-CoA levels and reduces lipopolysaccharide-induced neuroinflammation. Because intracellular acetyl-CoA can be used to alter histone acetylation-state, using Western blot analysis, we measured the temporal effect that acetate supplementation had on brain and liver histone acetylation following a single oral dose of glyceryl triacetate (6 g/kg). In parallel experiments, we measured the effect that acetate supplementation had on histone deacetylase (HDAC) and histone acetyltransferase (HAT) enzymic activities and the expression levels of HDAC class I and II enzymes using Western blot analysis. We found that acetate supplementation increased the acetylation-state of brain histone H4 at lysine 8 at 2 and 4 h, histone H4 at lysine 16 at 4 and 24 h, and histone H3 at lysine 9 at 4 h following treatment. No changes in other forms of brain or liver H3 and H4 acetylation-state were found at any post-treatment times measured. Enzymic HAT and HDAC assays on brain extracts showed that acetate supplementation had no effect on HAT activity, but significantly inhibited by 2-fold HDAC activity at 2 and 4 h post-treatment. Western blot analysis demonstrated that HDAC 2 levels were decreased at 4 h following treatment. Based on these results, we conclude that acetyl-CoA derived from acetate supplementation increases brain histone acetylation-state by reducing HDAC activity and expression.

Alzheimer’s and MT Promoter Therapy

Alzheimer’s and MT Promoter developed by Dr William Walsh Phd.

NOTES FROM 10/18/16

Notes from Dr Walsh’s presentation at the October 2016 Physician Workshop and Training Conference.

Alzheimers was named after the Doctor bearing his name. Hallmarks of this condition include

  1. Apoptosis – spontaneous death of cells at rate of 5000 times normal.
  2. Severe oxidative stress – inflammation and tissue damage.
  3. Neurofibrillary tangles – twisted fibers inside brain cells. Derived from microtubules that are responsible for transporting nutrients to nerve cells.
  4. Metal problems – initially believed to be aluminum, then brain volume, then concentration of aluminum. Theory of metal toxicity is back in favor with issues of role of copper and zinc recognized as playing a more important role.

Dr Walsh has developed an amino acid blend, called MT Promoter which is intended to improve metallothionein protein production. One such protein, ceruloplasmin is important for binding or chelating ‘free metals’. Unbound copper and other metals are free radicals that cause tissue damage. From a neurotransmitter standpoint, free copper lowers dopamine, the reward and executive thought neurotransmitter, and raises levels of norepinephrine, an excitatory neurotransmitter.  To prevent this conversion and avoid other effects of oxidative stress, we like to increase these binding proteins. In addition to MT Promoter, binding proteins level improves with improved consumption and digestive uptake of protein.  Metallothionein proteins are found in border cells of the digestive track and brain. They are believed to be a first line of defense against free radical damage.

There are believed to be two types of Alzheimer’s conditions:

  1. Genetic – runs in some families – out of 5-6 siblings, 1-3 will get this, as they get progressively older
  2. ApoE – genetically expressed proteins – Believed now that 50% of people 85+ have some amount

 

Signs and symptoms of progressive worsening condition:

  1. Early warning signs – often as early as 55-60 years old
    1. Lose interest in schedules – move away from life
    2. MCI
    3. Why recent/old – as memories formed, as sensory nerves strike outer part of brain and lay down inputs, memories are processed, info transferred to hippocampus and base of brain parts, processed/organized, then back where it came from and laid down as memory
  2. Moderate symptoms
    1. Inability to form new memories
    2. Years 4-6
    3. Often require nursing home – though may not be bothered by this
  3. Later stage
    1. Awful
    2. Complete loss of speech and response
    3. Some may have some understanding of who’s there but unable to respond

Risk Factors for Alzheimer’s

  1. Only realized in mid-50s had something to do with age
    1. Prior didn’t have long enough lifespan
  2. Many documented cases of boxers
    1. Family of well-known boxers in England – all developed
    2. Also football players – more and more cases now
  3. Education – big surprise
    1. Someone in MI developed ability to measure amyloid plaque level in alive human being – proportional to disorder in autopsies
    2. People who never went past HS, vs. college – factor of 5 difference – Even stronger if didn’t finish 8th grade
  4. Keep mind as active as possible
    1. If retired and learn new language or learn something new
  5. Sedentary FAR more likely
  6. Vascular Alzheimer’s Disease – not vascular dementia
    1. Most begins very close to blood vessels
    2. People with hypertension AND hypotension are more prone
  7. Alcohol abuse – factor 2-3
  8. Toxic metals – seen in high levels
  9. Poor nutrition
    1. Lots to do with glial cells nourishing all neurons
    2. Need nutrition to stay healthy, or neurons deteriorate and die

 

Diagnostic tests for Alzheimer’s:

  1. MMSE – common
  2. Best test – CANTAB – from Yale
    1. Like video game test – spend 45” going through the test
    2. Measures many cognitive functions, not just memory
    3. He got that to test his people pre/post
  3. Odor discrimination – entorhinal cortex is first to go
    1. Scratch and sniff, differentiate smells in multiple choice
    2. Correctly tell 10+ – very low likelihood of Alzheimer’s Disease development
    3. If 2-4, chances within 5 years much higher
    4. He gave to a good friend, who flunked the test – dad had died of Alzheimer’s Disease
      1. Had been getting affairs in order, then found out had a bad cold that day!
      2. Totally normal on retest, repeated since
    5. Direct measure
      1. Not yet FDA approved – research only

Theories:

  1. Ach
  2. Amyloid – losing favor
    1. They have gunky material in brain when they die
    2. As it grows, when it touches neuron, it dies – they thought
    3. 12-13 years ago – discovered drug to eliminate plaque from rat brains, rushed to human testing
      1. At first, so exciting. Got rid of plaques with mild-mod Alzheimer’s Disease
      2. Bad news – didn’t change trajectory of disease – still deteriorate and die
    4. Tau
      1. Makes the tangles
      2. Still leading theory
    5. Inflammation
      1. Could be this alone?
      2. Curcumin theory – India incidence of Alzheimer’s Disease in old people – 90yo – very small
        1. Curcumin very able to reduce inflammation in brain
      3. Oxidative stress
        1. Present in almost every neurodegenerative condition
      4. Toxic metal causation
        1. Persuasive Alzheimer’s Disease research on copper
      5. Could also be glial and nutrition related

ApoE isoforms:

  1. Small protein, linear
  2. Cysteine is great antioxidant
  3. When replaced progressively by arginine, raises risk
  4. Most people with Apoe4 don’t get it – 40-45%
  5. 40% of Alzheimer’s Disease have neither

FDA approved:

  1. Can improve symptoms 6-12 months (actually 4-6 in practice)
  2. Does not stop progress
  3. Enables dying brain to function a bit better – just what’s left works better

Case for Metallothionein:

  1. As much as anything else in brain, protective of metals
  2. If don’t have above-average levels of these metals, highly unlikely to form plaques
  3. Fresh brains with and w/o Alzheimer’s Disease – those who died OF Alzheimer’s Disease had less than 1/3 of normal conc
  4. Very intriguing

MT Promoter for Alzheimers:

  1. He had already developed for autism
  2. Formulation of 22 nutrients that promote synth and fxn of MT
    1. They looked at over 900 studies to see which nutrients promote expression of Alzheimer’s Disease, and which promoted function of brain once expressed
    2. They found by taking it themselves that there ARE side effects if low in Zn
    3. Zn is a metal-regulating element actually on DNA – tends to promote expression of MT
    4. But, it gets expressed without Zn (naked molecule) which immediately grabs Zn, dropping blood level, and causing irritability
  3. Zn loading followed by MTP
    1. Do this till plasma zinc reaches 100 mcg/dL
  4. Aimed at overcoming brain oxidative stress and inflammation, and repair of the BBB
    1. Prevents bad stuff from coming in

MT Promoter for Alzheimer’s Disease:

  1. Unproven until RCTs confirm efficacy
  2. Very promising results
  3. Don’t give to anyone without good quality of life – don’t preserve them in state of misery, so NOT advanced
  4. Have to have caretaker

Pyrrole Disorder and Depression

Among 10’s of thousands of individuals tested with depression, 15% turned out positive for pyrrole disorder known as kryptopyrroles. 

Biotype Pyrrole Depression

Patients who present with pyrrole disorder often are high in oxidative stress, suffer from severe mood swings and explosive anger, have extreme anxieties and fears, have poor short-term memory, and may have little or no dream recall. Depression strikes this subgroup usually because their kryptopyrroles are lost to their urine, which carries away the much needed B6 and Zinc.  Therefore these persons benefit greatly and often quickly from supplements of Vitamin B6 and P5P , both crucial to serotonin synthesis, and zinc supplementation. Pyrolurics also need more Omega 6 fats such as animal fat, borage or primrose oil  instead of Omega 3 fatty acids such as fish oils.  This inflammatory condition also benefits greatly from antioxidants such as Vitamin A, Vitamin D, Vitamin E, and Vitamin C.

Diagnosed with AD(H)D?  Anxiety?  Bipolar?  Depression?  It could be Pyrrole Disorder.  A high incidence of Pyrrole Disorder is found in individuals with depression, anxiety disorder, ODD, , bipolar disorder and AD(H)D.  Pyrrole Disorder is associated with elevated pyrroles in urine and severe deficiencies of zinc and pyridoxine (Vitamin B-6) throughout the body.  Ask yourself if you are experiencing symptoms of pyroluria. 

 
Testing for pyrrole disorder:  
Second Opinion Physician will arrange to have urine test kits sent to your home to determine your level of urinary pyrroles. 
 
Pyrrole Disorder Treatment:
 
You will be given a customized supplement plan that you may take to your local vitamin supplier or else use our recommended professional sources online. Second Opinion Physician provides product codes, dosages and times per day each supplement should be taken for your specific level of imbalance.
 
Temper Dysregulation Disorder 
 
Many children with severe temper tantrums, learning disabilities and oppositional defiant disorders actually suffer from pyrrole disorder. 
 

Symptoms of Pyrrole Disorder vary but may include:

                Urine

Elevated kryptopyrroles

Mauve colored urine

Digestive

Morning nausea

Tendency to delay or skip breakfast

Very dry skin

Affinity for spicy and salty foods

Body Features

Pale skin, inability to tan

White spots in nail beds

Sensitivity to bright lights

Sensitivity to loud noises

Poor wound healing

Joint pains

Premature graying of hair

Psoriasis

Delicate facial features

“Fruity” breath and/or body odor

Coarse eyebrow hair

Sretch marks (striae) on skin

Long arms, legs and fingers

Mood and Emotions

Extreme mood swings

Severe inner tension

Severe anxiety

Tendency to stay up very late

High irritability and temper

History of underachievement

Histrionic behavior

Severe depression

Fear of airplane travel, tornadoes, etc.

Obsessions with negative thoughts

Dreams and Memory

Little or no dream recall

Poor short-term memory

History of a reading disorder

Immunity and Inflammation

Autoimmune disorders

Severe oxidative stress

Poor growth

Delayed puberty

Spleen-area pain

Frequent infections

Abnormal EEG

Hormonal

Abnormal fat distribution

Abnormal or absent menstrual periods

Poor muscle development

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Medical Marijuana Resources

Recently searching for a strain of medical marijuana with a street name of ACDC, I came across the site . These guys are by far the most useful of medical marijuana resources.

Digging around the site I found mention of Rafael Mechoulam, the Israeli researcher who originally isolated THC.  If you’re looking for high CBD/THC ratios then ACDC is the strain for you. Mechoulam has studied this particular strain and found it highly effective for treating , , crohns disease, ADHD and insomnia. Some strains, namely Rafael’s have CBD percentage as high as 18.5%

Geekwire describes Leafly

And frankly, it’s not all that surprising considering the lack of superior competition and Leafly’s overall user experience. The site lets you easily explore over 500 strains that differ in their abilities to treat symptoms like anxiety and pain while providing effects like euphoria and creativity. People can filter out unwanted strains based on medical use and effect to the body on a neat interface that mimics a periodic table.

“It’s no diferent from Consumer Reports or Amazon when comparing the same product or similar products,” Kennedy said.

Each strain has an overall rating based on user reviews — there are over 50,000 of them — that people can read. Photos are also available with a clever “safe-for-work,” default option set up.

Essentially, Leafly is an information resource to help medical marijuana patients find the right strain. Kennedy said most people don’t realize that doctors will recommend medical marijuana treatment but don’t specify which strain.

“It’s like a doctor telling you that you have an infection and you should try taking an antibiotic without actually directing you to a specific one,” Kennedy explained. “Medical marijuana patients have a right to information about this medicine and that’s what we provide.”

You’re also able to find out which dispensaries are currently in stock with the specific strain, which is the other part of Leafly. There are 2,600 searchable dispensaries across the 17 states where it’s legal to buy medical marijuana. Users can enter in a city, state or zip and add filters like “credit card,” or “online menu.” There are over 10,000 dispensary reviews — in this aspect, it’s very similar to Yelp.