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pyrrole disorder zinc deficiency

Pyrrole Disorder and Depression

Among 10’s of thousands of individuals tested with depression, 15% turned out positive for pyrrole disorder known as kryptopyrroles. 

Biotype Pyrrole Depression

Patients who present with pyrrole disorder often are high in oxidative stress, suffer from severe mood swings and explosive anger, have extreme anxieties and fears, have poor short-term memory, and may have little or no dream recall. Depression strikes this subgroup usually because their kryptopyrroles are lost to their urine, which carries away the much needed B6 and Zinc.  Therefore these persons benefit greatly and often quickly from supplements of Vitamin B6 and P5P , both crucial to serotonin synthesis, and zinc supplementation. Pyrolurics also need more Omega 6 fats such as animal fat, borage or primrose oil  instead of Omega 3 fatty acids such as fish oils.  This inflammatory condition also benefits greatly from antioxidants such as Vitamin A, Vitamin D, Vitamin E, and Vitamin C.

Diagnosed with AD(H)D?  Anxiety?  Bipolar?  Depression?  It could be Pyrrole Disorder.  A high incidence of Pyrrole Disorder is found in individuals with depression, anxiety disorder, ODD, , bipolar disorder and AD(H)D.  Pyrrole Disorder is associated with elevated pyrroles in urine and severe deficiencies of zinc and pyridoxine (Vitamin B-6) throughout the body.  Ask yourself if you are experiencing symptoms of pyroluria. 

 
Testing for pyrrole disorder:  
Second Opinion Physician will arrange to have urine test kits sent to your home to determine your level of urinary pyrroles. 
 
Pyrrole Disorder Treatment:
 
You will be given a customized supplement plan that you may take to your local vitamin supplier or else use our recommended professional sources online. Second Opinion Physician provides product codes, dosages and times per day each supplement should be taken for your specific level of imbalance.
 
Temper Dysregulation Disorder 
 
Many children with severe temper tantrums, learning disabilities and oppositional defiant disorders actually suffer from pyrrole disorder. 
 

Symptoms of Pyrrole Disorder vary but may include:

                Urine

Elevated kryptopyrroles

Mauve colored urine

Digestive

Morning nausea

Tendency to delay or skip breakfast

Very dry skin

Affinity for spicy and salty foods

Body Features

Pale skin, inability to tan

White spots in nail beds

Sensitivity to bright lights

Sensitivity to loud noises

Poor wound healing

Joint pains

Premature graying of hair

Psoriasis

Delicate facial features

“Fruity” breath and/or body odor

Coarse eyebrow hair

Sretch marks (striae) on skin

Long arms, legs and fingers

Mood and Emotions

Extreme mood swings

Severe inner tension

Severe anxiety

Tendency to stay up very late

High irritability and temper

History of underachievement

Histrionic behavior

Severe depression

Fear of airplane travel, tornadoes, etc.

Obsessions with negative thoughts

Dreams and Memory

Little or no dream recall

Poor short-term memory

History of a reading disorder

Immunity and Inflammation

Autoimmune disorders

Severe oxidative stress

Poor growth

Delayed puberty

Spleen-area pain

Frequent infections

Abnormal EEG

Hormonal

Abnormal fat distribution

Abnormal or absent menstrual periods

Poor muscle development

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pyrrole disorder depression

The Role of Pyrroles in Depression

#, also known as pyroluria or mauve factor, is a condition in which elevated levels of urinary due to oxidative stress. It is often brought on or exacerbated by physical and emotional distress. This may be the trigger that causes one to suddenly develop an imbalance in the breakdown of hemaglobin. This leads to chronic and vitamin B6 deficiencies due to the fact that pyrroles are aldehyde chelators and they attract and subsequently deplete zinc and B6.  This is a chronic disorder that affects roughly 10% of the population, and is especially prominent in those suffering from behavioral and mood disorders such as , , , bipolar, and .  Unfortunately, while doctors learned about this condition in medical school it is rarely acknowledged or investigated by general practitioners and psychiatrists, much less diagnose. Yet the treatment with supplements is simple and in many cases highly effective.

Some of the common symptoms are: , mood swings, depression, auditory processing disorder, memory loss, joint pain, poor dream recall, Irritable bowel syndrome, as well as being associated with internal stress and low serotonin production. Folks with zinc deficiency can often screen themselves by looking at their nail beds. If there are white clouds under the nail, this is a pretty good sign to get yourself checked out.

Following is an article excerpt from the story of one child’s Kryptopyrrole diagnosis, and she and her family’s journey from daily struggle into thriving and well-being…

Here’s an good example of what to expect with urinary pyrroles from Body and Soul:
Read full article here: Body & Soul, 10% Have This Illness But Most Don’t Know It

“We saw various experts trying to find out what was wrong and received various diagnoses, before taking Sophie to a physiotherapist who did cranial and visceral manipulation. She told me there was a problem with Sophie’s gut and recommended we see a GP who specialised in that area. She diagnosed pyrroles disorder.

Unusually, I had heard of pyrrole, as a friend’s son had it. It’s a genetic blood disorder that results in a dramatic deficiency of zinc, vitamin B6 and arachidonic acid – a long-chain##### fat.

Common symptoms include inability to cope with stress, emotional mood swings and sensitivity to light and sound. It also causes learning difficulties and auditory processing disorder, which means that in a noisy environment, it’s hard to single out the sound you should be listening to. In a classroom environment, that would mean that if other kids were talking, Sophie would struggle to hear the teacher.

It all made perfect sense and, sure enough, the urine test came back positive. The doctor told Sophie: “You poor thing, you really have been having a hard time of it, haven’t you?”, which was probably the best thing she could?have said. It was really nice for Sophie to have someone acknowledge her condition like that.

Sophie, now seven, was prescribed supplements in a dosage accordant with her weight and it made an immediate difference. We saw changes overnight and, although I know our journey is ongoing, it’s been getting better ever since. She was instantly happier, slept better and concentrated better. Before she couldn’t retain information or do spelling but now it was as if that blockage had been unblocked.”

Five Biotypes of Depression

The Five Biotypes of & Advanced Nutrient Therapies with William Walsh, PhD

Second Opinion Physician, David Epstein, D.O., is trained in the Walsh Protocol, developed by Dr. William J. Walsh, PhD, and committed to the natural treatment of depression, as well as other mood and behavioral disorders, thru the use of Nutrient Therapy.  It is estimated that 13.1 to 14.2 million American adults suffer from depression currently and that at least 32 million will similarly face this disease at some point in their lives.  However, the disease can be tricky to tackle for a number of reasons, not least of which are the grave misconceptions regarding depression which are upheld by mainstream psychiatry.  

Mainstream psychiatry typically regards depression as a “single entity with variations along a central theme”, according to Dr. Walsh.  It is also mostly assumed that those suffering from depression have low activity in the receptors in their brains responsible for the handling of serotonin, a monoamine neurotransmitter associated with feelings of “happiness and well-being”.  It is this central belief which informs most decisions as far as the majority of medications being used to treat depressive patients.  Most are prescribed SSRI medications which inhibit the reabsorption of serotonin into its originating receptor, thereby leaving more of the serotonin free to bind to postsynaptic receptors and to have positive effects, allegedly, on the entire organism.  However, after having evaluated 2,800 patients diagnosed with clinical depression, thru the lens of nutrient therapy, Dr. William Walsh is turning both of these centrally held misconceptions about depression and its treatment on their heads.  

By way of his evaluation and ongoing database studies, Dr. Walsh and his colleagues have identified five high-incidence depression biotypes.  These biotypes reference distinct and unique neurotransmitter & nutrient imbalances and symptoms, and therefore, according to Walsh, should be approached as 5 different disorders.  Additionally, he has made links between certain biotypes and the ineffectiveness of SSRI medications, even identifying some subgroups for whom SSRIs are actually dangerous.  

The biotype studies have given us great insight into these different depressive disorders, as well as a more workable look into what causes depression. Using this new revolutionary approach, Second Opinion Physician is able to direct patients towards lab tests which can identify the very nutrient & neurotransmitter imbalances triggering their particular depression, and can then provide recommendations for natural, highly effective, and individualized treatments.  This treatment will most often fall within the spectrum of about 6-8 different natural , along with dosage recommendations specific to the individual’s other biochemical status. 

A brief breakdown of each of the 5 Biotypes of Depression can be found below.

A note from our physician: Any one person will have variable combinations so the treatment must be individualized. I don’t recommend anyone trying to treat themselves based on this information unless a lab test is performed and a trained practitioner is coaching the individual. Follow link to learn more:

BIOTYPE 1 – Undermethylators – 38% of depression population

BIOTYPE 2 – Overmethylators  – or “Low-Folate Depressives” – 20% of depression population

BIOTYPE 3 – Pyrroluria or Pyrrole Depression – 15% of depression population

BIOTYPE 4 – Copper Overload or “High-Copper Depression” – 17% of depression population

95% of the patients in this subgroup are female.  Overly high copper levels can result in elevated norepinephrine and reduced dopamine in patients, high-anxiety and a tendency for panic, a high incidence of postpartum depression, estrogen intolerance, tinnitus, and extremely sensitive skin.  These persons are typically experiencing oxidative stress throughout their body as they have a limited ability to manage free radicals, such as heavy metals. Working to lower copper levels would be the nutrient therapy approach, but caution must be taken to not lower levels too quickly as it will temporarily worsen effects (due to copper leaving tissue and dumping into the blood or digestive tract).  Recommended supplements may include zinc, molybdenum, manganese and chromium (trace elements) and metalothionine producing amino acids. SSRIs are generally reported as ineffective for those suffering from High-Copper Depression.

BIOTYPE 5 – Toxic Metal Depression (5%)

These individuals have an excessive metal burden, such as lead toxicity.  They often exhibit severe oxidative stress, unrelenting depression, abdominal stress, a metallic taste in the mouth and bad breath, high levels of irritability or anger, and food sensitivities.  A gradual detox regimen might include supplements such as ALA, trace elements, metalothionine amino acids and antioxidants.  SSRIs are generally reported as ineffective for the Toxic Metal subgroup of patients struggling with depression.

Thanks to the dedicated work of Dr. William J. Walsh and other pioneers in the fields of nutrient therapy and , we now have more insight into some of the actual causes of depression, and can apply more targeted, individualized, effective, and safe treatments for patients.  Thru the recommendation of lab tests and subsequently the application of the various possibilities for nutrient and supplement based therapy, Second Opinion Physician can help patients finally break free from the painful and often debilitating struggle with depression, and other mood or behavioral disorders, to find relief and reclaim balance and health.d

Watch Video for more details:  Dr. William J. Walsh speaking to the American Nutrition Association about the 5 Biotypes of Depression and Advanced Nutrient Therapies

This is a simple summary followed by video of Dr Walsh explaining this in detail at the American Nutrition Association in 2014.

Any one person will have variable combinations so the treatment must be individualized. I don’t recommend anyone trying to treat themselves based on this information unless a lab test is performed and a trained practitioner is coaching the individual. There is usually about 6-8 different supplements and dosages recommended for the five  biotypes of depression, but it works something like this.