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Methylation and Epigenetics – William Walsh PhD Podcast

Methylation Overview:

New discoveries in the field of epigenetics have led to effective advanced nutrient therapies for children and adults challenged by brain disorders, such as autism, Alzheimer’s, depression, bipolar, schizoaffective disorders, and ADHD/ADD. A Walsh panel can determine a clients’ methylation status, and thus a treatment based on their biochemical individuality. Dr. David Epstein, D.O., offers full assessments and specific recommendations to clients according to the Walsh protocol. Second Opinion Physician is a holistic telemedicine practice, specializing in nutrient therapies developed by Dr William J Walsh and the Walsh Research Institute.

Podcast below provide by:

The CoreBrain Journal Walsh Molecular Series: 

Dr Walsh provides a more detailed description of the significance of methylation and epigenetics and the consequence of undermethylation or overmethylation on mood and mental function. CLICK ARROW BELOW TO BEGIN:

 

About Dr Walsh               

William J. Walsh, PhD, FACN, president of the nonprofit Walsh Research Institute, is an internationally recognized expert in the field of nutritional medicine and a key scientist paving the way for nutrient-based psychiatry and nutritional medicine.  Over the past 30 years, Dr. Walsh has developed biochemical treatments for patients diagnosed with behavioral disorders, attention deficit (hyperactivity) disorder, autism, clinical depression, anxiety, bipolar disorders, schizophrenia, and Alzheimer’s disease that are used by doctors throughout the world.

His book, Nutrient Power: Heal Your Biochemistry and Heal Your Brain [updated May 2014], describes specific findings for his evidence-based nutrient therapy system.

Dr. Walsh’s noted accomplishments include:  (a) groundbreaking studies reporting reduced violent behavior following nutrient therapy, (b) the 1999 discovery of undermethylation and copper/zinc imbalances [Coming: CBJ/034] in autism, (c) the 2000 finding of metallothionein protein depletion in autism, (d) the 2007 published study linking copper overload and post-partum depression, (e) the identification of five biochemical subtypes of clinical depression, (f) the 2011 development of the Walsh Theory of Schizophrenia [Coming: CBJ/042], and (g) the direction of the Beethoven Research Project that revealed that the composer suffered from severe lead poisoning.

His internationally acclaimed presentations, including for the American Psychiatric Association, affirm his important contributions to both functional and traditional medical groups.

Clinical Experience

After earning degrees from Notre Dame and the University of Michigan, Dr. Walsh received a PhD in chemical engineering from Iowa State University.  While working at Argonne National Laboratory in the 1970s, Dr. Walsh organized a prison volunteer program that led to studies of prisoners and ex-offenders researching the causes of their violent behavior.  The collaboration with renowned (late) Carl C. Pfeiffer, MD, PhD, a pioneer in the field of nutritional research therapy, led Dr. Walsh to the development of individualized nutrient protocols to normalize body chemistry and brain chemistry. Dr. Walsh went on to study more than 30,000 patients with mental disorders acquiring an unparalleled database of more than 3 million chemical assays during his clinical and research work.

NB: Dr. Walsh has conducted chemical analysis of more than 25 serial killers and mass murderers, including Charles Manson, Richard Speck, James Oliver Huberty, Patrick Sherrill and Arthur Shawcross.  He has assisted medical examiners, coroners, Scotland Yard, and the FBI in these forensics studies. He has designed nutritional programs for Olympic athletes, NBA players, major league baseball players, a heavyweight boxing champion, PGA and LPGA golfers, and others.

 

Treat Elevated Histamine, Naturally

Whole blood histamine levels are tested when determining cause of depression and other mood disorders.

Histamine is reduced or broken down by methyl compounds and so with high histamines the body may become depleted in the methyl groups. Because histamine depletes methyl compounds, it is easy to identify ones methylation status from their histamine levels. Elevated histamine depletes methyl compounds and the resulting undermethylation leads to depression and a host of other mood disorders.

Some common symptoms of undermethylation:
·    OCD obsessive compulsive tendencies
·    SAD Seasonal affective disorder
·    Competitive & perfectionist
·    SSRI medications usually effective
·    Calm exterior with inner tension
·    Strong willed
·    High libido
·    Seasonal allergies

Using the Walsh protocol to treat undermethylation I recommend supplements high in methyl compounds such as the amino acid methionine and SAMe (s-adenosyl methionine).

Diet is also an important factor. Foods that are high in methionine include lean meats, egg whites, poultry, halibut and other fish, soy beans, white beans and brazil nuts. SAMe and methionine help break down histamine by methylating it. Vegetarians and people with high histamine have a hard time getting sufficient methyl compounds in their diets and should be encouraged to take methionine supplements.

Histamine Intolerance:
Another approach to improving methylation status lies in reducing histamine levels in the first place. To this requires a study of one’s health condition and assessment of factors that raise histamine.

Histamine rich foods: Foods that are associated with high histamine levels include fermented foods such as sauerkraut, kombucha, pickles, wine, yogurt, mature cheeses and fermented soy products. It also includes cured, smoked and fermented meats such as salami and sausage, etc. Tomato paste, spinach and canned fish products also have high histamine levels. Citrus foods are histamine liberators which increase histamine release and so should also be avoided.

Histamine is chemically known as a “biogenic amine”. Fermented foods have high levels of these biogenic amines. These are foods that are exposed to microbial decomposition as part of the fermentation or in storage. Lactic acid bacteria are the most problematic biogenic amine producers in fermentation. These bacteria break down amino acids into amine-containing compounds. Biogenic amines are commonly found in wines, cider, dairy, meat, fish, beer, spinach, tomatoes and yeast. Biogenic amines in the form of histamine are the product of bacteria breaking down amino acids. Control biogenic amines to treat elevated histamine

Diamine Oxidase DAO
This is an important enzyme that naturally lowers histamine levels in the body. DAO can be provided as a supplement to lower histamine levels. Symptoms of low DAO includes:
·    Skin irritations – hives, itching, rashes, eczema, psoriasis, and acne
·    Headaches
·    Painful menstrual periods
·    Gastrointestinal symptoms
·    Intolerance to fermented foods and alcohol
·    Mucous in sinuses
·    Asthma

Supplements and OTC meds that increase DAO levels include:
·    Vitamin C
·    Vitamin B6
·    Pancreatic enzymes
·    Benadryl

Foods and meds that inhibit DAO
·    Alcohol
·    Curcumin (turmeric)
·    Cimetidine – an antihistamine

 

Histamine and Mast Cells
Histamine is released from “mast cells”. Mast cells are immune cells that line the mucous membranes of the sinuses, digestive tract, the skin, lungs, eyelids, and tissues surrounding blood vessels and nerves. Activation of mast cells plays a key role in asthma, rhinitis, eczema, itching, pain, autoimmunity and hives. Elevated mast cells are associated with female infertility and decreased sperm motility. Stabilize mast cells to treat elevated histamine.

Supplements that stabilize mast cells:
·    Quercitin
·    Curcumin (also decreases DAO)
·    Reishi mushrooms
·    Yohimbine
·    Adrenaline
·    Eleuthero
·    Rutin
·    Theanine
·    Astragalus

Cortisol and Corticotropic Releasing Hormone CRH
It is commonly believed that cortisol causes allergies. That’s only part of the picture. The fact is that cortisol itself lowers histamine levels. It is the hormone that stimulates the adrenal release of cortisol that causes histamine release from mast cells. Chronically elevated CRH is associated with stress, as the release of CRH causes cortisol release from the adrenal glands. Under chronic stress, cortisol levels are low as the adrenal glands become exhausted and cannot produce sufficient cortisol. Yet the CRH hormone is likely elevated in chronic stress because the  hypothalamus releases CRH via the HPA axis as the body is trying to induce more cortisol to address the stress perceived by the brain. Chronic stress is thereby a major cause of histamine release from mast cells due to the effect of corticotropic releasing hormone CRH. We can make assumptions about the level of CRH and cortisol by testing salivary cortisol levels. Because they have a circadian rhythm we test four salivary cortisol levels in a day to establish the overall performance and need for supplementation. Treating elevated cortisol or depressed cortisol levels requires a salivary cortisol test and understanding of the underlying condition.

Herbs and cortical extracts are used to down regulate or supplement the adrenal gland performance. This has the effect of lowering CRH and mast cell release of histamine.

Histamine and Lectins
Foods such as potatoes are high in lectins. Lectins can bind the lining of the intestinal wall and cause leaky gut syndrome. Undigested lectins then enter the blood system and lead to antibody formation and which releases histamine. Foods high in lectins include:

·    White potatoes and unmodified potato starch
·    Tomatoes
·    Soy
·    Gluten containing grains
·    Legumes

Histidine Decarboxylase HDC
The conversion of the amino acid histidine into histamine takes place with the help of HDC enzyme. It is possible to slow the conversion of histidine to histamine by inhibitors of HDC.

Inhibitors of HDC are:
·    Cortisol
·    Catechins – found in green tea, chocolate, kola nut, peaches, acai, apricots, apples, blackberries, raspberries, plums with skin and broad beans
·    SAMe
·    NAC N-acetyl cysteine
·    Homocysteine
·    Carnosine
·    Treat any underlying infection of H Pylori (very common with gastritis)

Histamine and Probiotics
Probiotics in the digestive tract are responsible for producing many compounds in the body. There are bacterial strains that increase histamine as well as intestinal microbes that reduce histamine.
Decreases histamine –  B infantis, B lognum and L plantarum
Increases histamine – L casei, L reuteri and L bulgaricus

Summary of supplements and recommendations to lower histamine while treating undermethylation:

·    Take methionine (500mg-1gm) and SAMe (200mg) supplements
·    DAO diamine oxidase enzymes 2-3 caps
·    Probiotics B infantis, B longum, L plantarum
·    Vitamin C 1000 mg
·    B6 (can also increase histamine carboxylase)
·    Avoid lectin in diet – potatoes and tomatoes
·    Avoid fermented foods
·    Increase proteins high in methionine
·    Use Cromolyn – OTC mast cell stabilizer
·    Bendryl
·    Bromelain and Quercitin
·    Chocamine 1-3 grams – mast cell stabilizer
·    Improve adrenals with herbal and glandular supplements
·    Curcumin (also decreases DAO)
·    NAC N-acetyl cysteine
·    Catechins (green tea etc)

Natural Remedies for Mood Disorders

Pioneers in the field of Nutrient Therapy, such as Carl Pfeiffer, MD, PhD and William J. Walsh, PhD, President of the Walsh Research Institute, have found abnormalities in and elevated or reduced levels of histamines in the body to be central to many different behavioral or mood disorders, such as bipolar disorder, depression, anxiety, panic disorders, and even classical paranoid .  The effects of being over or under methylated or of having abnormalities in histamine levels are vast and often debilitating… but the good news is that there exists completely safe and natural remedies for these imbalances!  And the power, speed, and efficacy of these natural remedies can be a source of great hope and relief for sufferers of mood disorders, including depression, anxiety, and other upsetting conditions that are not uncommon in an increasingly toxic and often stressful modern way-of-life.

BIOTYPE 1 – Undermethylators (38% of depression population):

Some of the common characteristics of this depressive group are: OCD tendencies, calm exterior but high inner tension, competitive, perfectionistic, addictive tendencies, and high libido.  Undermethylators may be benefited by SSRI medications, but often with side-effects.  The Nutrient Therapy approach would most likely include the addition of methionine or SAMe. These amino acids contribute a methyl compound and increase total serotonin production.  Other important supplements include inositol, B6, calcium, magnesium and vitamin C.

Folic acid is absolutely not recommended for these types.

BIOTYPE 2 – Overmethylators (or “Low-Folate Depressives”) (20% of depressed population):

Some of the commonly recurring characteristics within this population are: high anxiety, panic, noncompetitive in sports or games, food/chemical sensitivities, high musical or artistic ability, underachievement, sleep disorders, and low libido.  This subtype tends to do poorly with methylation and in fact do very poorly with SSRI antidepressants. This is because they have plenty of serotonin, but they lack B12 and Folic Acid. Likewise, SAMe and methionine are not recommended.  An effective nutrient therapy would seek to enhance acetylation and suppress methylation for these patients, folate and niacinamide being excellent supplements for this.

Excellent Podcast Below Featuring William Walsh PhD on Bulletproof Radio Discussing Methylation

One-carbon (methyl) groups are integral to the synthesis of neurotransmitters, genetic expression, metabolism, and other crucial biochemical reactions.  Methylation, also referred to as the methyl/folate ratio, turns cells on and off through histone bodies which are connected to the .  DNA is responsible for the production of proteins which can express in the form of enzymes, hormones, inflammatory cells, neurotransmitters, and more.  Methylation affects anything that is produced by the differentiated cells of the body.  As far as brain function is concerned, methylation is a major player in the synthesis of serotonin, dopamine, and norepinephrine, three neurotransmitters whose proper balancing and healthy levels are essential for the maximized functioning of our brains and for the maintenance of a healthy emotional life.

In overmethylated patients there tends to be an abundance of serotonin, dopamine, and norepinephrine whereas undermethylated patients tend to be depleted in these essential neurotransmitters.  Within the realm of behavioral disorders, what is crucial is the enzyme which is responsible for returning serotonin to the originally releasing neurotransmitter (a process referred to as reuptake).

  • When methylation is high (“”), the enzyme levels that return serotonin back to the releasing neuron are low and there is increased serotonin activity.  When methylation is low (“”), the enzyme levels will be in excess and the serotonin activity will be low.
  • Additionally, overmethylation inhibits expression of the genes, of each cell in the body. It does this by causing a folding of the DNA structures. Undermethylation will cause DNA to unfold, making it more expressive.  Folding of the DNA diminishes the activity of that DNA which are responsible for the daily producing of critical hormones, enzymes and other types of proteins etc. All of these factors contribute to conditions ranging from autism to alzheimers, depression and anxiety. Understanding this new science gives us an opportunity to more successfully utilize natural remedies for mood disorders and healthy brain activity in general.

More than two decades ago, Dr. Pfeiffer studied the metabolism of over 20,000 patients suffering from schizophrenia and kept running into the phenomenon of severely deficient levels of histamine in these patients, later referring to this low histamine syndrome as “histapenia”.  Histapenia was found to be common in his classical paranoid schizophrenic patients, as well as those suffering from anxiety and panic disorders.  The histamine deficiency also coincided with nutrient deficiencies, specifically folic and and/or B12, and with an overload of copper.  Based on these findings, Dr. Pfeiffer enacted an aggressive therapy regime using B12, B3, and folic acid for these patients… and had tremendous success!  The patients experienced dramatic improvements, and Dr. Pfeiffer attributed the success to the elevation of histamine levels.  Ensuing studies have pointed to the role of the methyl/folate ratio and its normalization as being critical to these favorable outcomes.

  • Elevated histamine indicates undermethylation, and there are symptoms which may point to this being the case for an individual, for example: seasonal allergies, obsessive-compulsive tendencies, being strong-willed, perfectionism, and high-libido, just to name a few.
  • Some conditions associated with undermethylation are OCD obsessive compulsive disorder, trichotillomania, oppositional-defiant disorder, competitiveness, bulimia, anorexia, impulsivity (gambling/shopping disorders, etc), depression, schizoaffective disorder, and delusions.

On the other hand, overmethylated persons typically suffer from food/chemical sensitivities, dry eyes, and a severe intolerance to SSRI medications (such as Prozac, Celexa, Lexapro, Luvox, Paxil, Zoloft, etc), and have strong association with anxiety and panic disorders, low motivation, paranoid schizophrenia, hyperactivity, anxious depression, learning disabilities, and even hallucinations.

At Second Opinion Physician we request labs to be done for all patients (appropriate to the information gathered at initial consultation) in order to assess nutrient levels, and which includes testing for methylation levels, so that we might then effectively prescribe natural remedies for mood disorders.

  • If a patient is found to be overmethylated we typically treat with folic acid and B12, plus a focus on dietary considerations (for example, perhaps recommending an increase in animal skin, cartilage, and gelatin consumption in order to provide B vitamins and proteins which naturally counter excess methylation).  B12 and folic acid therapies can noticeably slow down methylation symptoms within 2 weeks to 2 months.
  • If methylation is low, we strive to increase serotonin production naturally, with supplements/nutrients such as B6 and Zinc and may recommend adding methionine to the patient’s diet, which comes naturally from muscle meats.  We may also recommend the addition of SAMe, which is a fast-acting and more readily available methylator.  Patients may see major effects with methionine in about 1-3 months, and even more quickly with SAMe treatment.

Methylation and histamine-level balancing is just one example of the nutrient-based approach to health taken by Second Opinion Physician.  By using natural remedies to balance brain chemistry and improve methylation status we can tackle even the most tenacious mood disorders, behavioral disorders, combat anxiety, and treat depression naturally to create more overall health and emotional balance for otherwise suffering individuals.

Listen to William Walsh PhD Podcast with Bulletproof Radio:

Play

Good Foods During Pregnancy

 We are all either undermethylators, overmethylators or normal methylators.

Many persons with depression are under or over methylators. Depressed women during pregnancy are frequently undermethylators. The good news is, there are many foods that provide to reverse the deficiency and lift depression. 

This published study in the Psych Congress Journal suggests that women who have maternal depression and are undermethylated, often give birth to children who experience depression due to their own ensuing condition of .

Whole blood histamine test is a lab that indicates methylation status. An excellent natural therapy may be methionine or SAMe supplements or foods that are high in methionine. If you have high blood histamines you may be undermethylated. Persons with seasonal allergies are frequently undermethylated. I recommend you get your levels tested before indulging in high methionine foods because your depression may in fact be associated with overmethylation, which requires an opposite approach, to lower methionine.

In consideration of the the study below, know your methylation status, particularly if you are depressed, and to combat during pregnancy, eat foods high in methionine and or take supplements. It won’t just make the mother feel better, but improves chance child won’t end up with depression.

Maternal Depression Linked to Methylation Changes in Offspring

by Will Boggs MD, Psych Congress

By Will Boggs MD

Maternal depression is associated with widespread changes in DNA methylation in their offspring that may persist into adulthood, researchers from Canada report.

“These data further demonstrate the potential long-term consequences of maternal depression for the health of future generations and the importance of mental health and social support of mothers and would be mothers for the physical health of newborn and children,” Dr. Moshe Szyf from McGill University in Montreal, Quebec, told Reuters Health by email. “What is remarkable is that the mental state of a mother causes changes in DNA methylation in the newborns in the immune system, not just the brain.”

Maternal mood disorders and stress during pregnancy can result in attention learning deficits during childhood and mood disorders during adulthood for their offspring. Evidence suggests these consequences may be mediated by modifications of DNA methylation levels.

Dr. Szyf’s team investigated possible associations between maternal depression and DNA methylation changes in T lymphocytes from neonatal cord blood and in hippocampal brain tissues from adults with or without histories of maternal depression.

Offspring of depressed mothers, however, showed significant differences in DNA methylation from those of nondepressed mothers in 145 T lymphocyte CG sites. Most (75.5%) were hypomethylated in the maternal depression group compared with the control group.

“One of the main surprises was that we found a larger effect of maternal depression on the babies’ DNA methylation than the maternal DNA methylation,” Dr. Szyf said. “The second surprise was that it seems that the effect is a consequence of lifelong depression rather than depression only around the pregnancy period.”

“For healthy babies to develop into healthy adults it is important to have healthy mothers,” Dr. Szyf said. “And this involves not only physical and metabolic health but also mental and social wellbeing. This hopefully will be an important pillar in prenatal care as well as public policy relating to preconception health.”

“The consequences of maternal depression might suggest using epigenetic interventions for prevention and reversal of the impacts of maternal depression on the offspring,” Dr. Szyf added. “One clinical potential of the data is the possibility of developing biomarkers of maternal depression that might serve as predictors of lifelong health risks and guide early interventions.”

Dr. Joanne Ryan from University of Melbourne’s Murdoch Childrens Research Institute, Australia, who recently reviewed and depressive disorders, told Reuters Health by email, “An important next step in this research is to determine whether these methylation differences and associated with health outcomes in the infants/children. Maternal depression during pregnancy has been associated with long-term negative outcomes in the child — the data from this study should be used to determine whether such effects can be mediated by differential DNA methylation.”

To find out more about good foods during pregnancy to help with low methionine, we checked with our favorite food resource.

http://nutritiondata.self.com/

Five Biotypes of Depression

The Five Biotypes of & Advanced Nutrient Therapies with William Walsh, PhD

Second Opinion Physician, David Epstein, D.O., is trained in the Walsh Protocol, developed by Dr. William J. Walsh, PhD, and committed to the natural treatment of depression, as well as other mood and behavioral disorders, thru the use of Nutrient Therapy.  It is estimated that 13.1 to 14.2 million American adults suffer from depression currently and that at least 32 million will similarly face this disease at some point in their lives.  However, the disease can be tricky to tackle for a number of reasons, not least of which are the grave misconceptions regarding depression which are upheld by mainstream psychiatry.  

Mainstream psychiatry typically regards depression as a “single entity with variations along a central theme”, according to Dr. Walsh.  It is also mostly assumed that those suffering from depression have low activity in the receptors in their brains responsible for the handling of serotonin, a monoamine neurotransmitter associated with feelings of “happiness and well-being”.  It is this central belief which informs most decisions as far as the majority of medications being used to treat depressive patients.  Most are prescribed SSRI medications which inhibit the reabsorption of serotonin into its originating receptor, thereby leaving more of the serotonin free to bind to postsynaptic receptors and to have positive effects, allegedly, on the entire organism.  However, after having evaluated 2,800 patients diagnosed with clinical depression, thru the lens of nutrient therapy, Dr. William Walsh is turning both of these centrally held misconceptions about depression and its treatment on their heads.  

By way of his evaluation and ongoing database studies, Dr. Walsh and his colleagues have identified five high-incidence depression biotypes.  These biotypes reference distinct and unique neurotransmitter & nutrient imbalances and symptoms, and therefore, according to Walsh, should be approached as 5 different disorders.  Additionally, he has made links between certain biotypes and the ineffectiveness of SSRI medications, even identifying some subgroups for whom SSRIs are actually dangerous.  

The biotype studies have given us great insight into these different depressive disorders, as well as a more workable look into what causes depression. Using this new revolutionary approach, Second Opinion Physician is able to direct patients towards lab tests which can identify the very nutrient & neurotransmitter imbalances triggering their particular depression, and can then provide recommendations for natural, highly effective, and individualized treatments.  This treatment will most often fall within the spectrum of about 6-8 different natural , along with dosage recommendations specific to the individual’s other biochemical status. 

A brief breakdown of each of the 5 Biotypes of Depression can be found below.

A note from our physician: Any one person will have variable combinations so the treatment must be individualized. I don’t recommend anyone trying to treat themselves based on this information unless a lab test is performed and a trained practitioner is coaching the individual. Follow link to learn more:

BIOTYPE 1 – Undermethylators – 38% of depression population

BIOTYPE 2 – Overmethylators  – or “Low-Folate Depressives” – 20% of depression population

BIOTYPE 3 – Pyrroluria or Pyrrole Depression – 15% of depression population

BIOTYPE 4 – Copper Overload or “High-Copper Depression” – 17% of depression population

95% of the patients in this subgroup are female.  Overly high copper levels can result in elevated norepinephrine and reduced dopamine in patients, high-anxiety and a tendency for panic, a high incidence of postpartum depression, estrogen intolerance, tinnitus, and extremely sensitive skin.  These persons are typically experiencing oxidative stress throughout their body as they have a limited ability to manage free radicals, such as heavy metals. Working to lower copper levels would be the nutrient therapy approach, but caution must be taken to not lower levels too quickly as it will temporarily worsen effects (due to copper leaving tissue and dumping into the blood or digestive tract).  Recommended supplements may include zinc, molybdenum, manganese and chromium (trace elements) and metalothionine producing amino acids. SSRIs are generally reported as ineffective for those suffering from High-Copper Depression.

BIOTYPE 5 – Toxic Metal Depression (5%)

These individuals have an excessive metal burden, such as lead toxicity.  They often exhibit severe oxidative stress, unrelenting depression, abdominal stress, a metallic taste in the mouth and bad breath, high levels of irritability or anger, and food sensitivities.  A gradual detox regimen might include supplements such as ALA, trace elements, metalothionine amino acids and antioxidants.  SSRIs are generally reported as ineffective for the Toxic Metal subgroup of patients struggling with depression.

Thanks to the dedicated work of Dr. William J. Walsh and other pioneers in the fields of nutrient therapy and , we now have more insight into some of the actual causes of depression, and can apply more targeted, individualized, effective, and safe treatments for patients.  Thru the recommendation of lab tests and subsequently the application of the various possibilities for nutrient and supplement based therapy, Second Opinion Physician can help patients finally break free from the painful and often debilitating struggle with depression, and other mood or behavioral disorders, to find relief and reclaim balance and health.d

Watch Video for more details:  Dr. William J. Walsh speaking to the American Nutrition Association about the 5 Biotypes of Depression and Advanced Nutrient Therapies

This is a simple summary followed by video of Dr Walsh explaining this in detail at the American Nutrition Association in 2014.

Any one person will have variable combinations so the treatment must be individualized. I don’t recommend anyone trying to treat themselves based on this information unless a lab test is performed and a trained practitioner is coaching the individual. There is usually about 6-8 different supplements and dosages recommended for the five  biotypes of depression, but it works something like this.