Serious conditions such as panic disorders, Biopolar disorder and schizophrenia are often suffering from overmethylation. Serotonin, dopamine and norepinephrine are elevated in these persons. It is possible to diagnose this condition through a whole blood histamine test or else through a SAM/SAH methylation ratio test. Higher levels of these neurotransmitters can cause anxieties, disorders and in some cases psychosis and maybe lead some to suicide. Fortunately supplementation can reverse the symptoms associated with overmethylation. The goal is to reduce the methylation effect of elevated neurotransmitters and lower oxidative stress.