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Pyrrole Disorder and Depression

Among 10’s of thousands of individuals tested with depression, 15% turned out positive for pyrrole disorder known as kryptopyrroles. 

Biotype Pyrrole Depression

Patients who present with pyrrole disorder often are high in oxidative stress, suffer from severe mood swings and explosive anger, have extreme anxieties and fears, have poor short-term memory, and may have little or no dream recall. Depression strikes this subgroup usually because their kryptopyrroles are lost to their urine, which carries away the much needed B6 and Zinc.  Therefore these persons benefit greatly and often quickly from supplements of Vitamin B6 and P5P , both crucial to serotonin synthesis, and zinc supplementation. Pyrolurics also need more Omega 6 fats such as animal fat, borage or primrose oil  instead of Omega 3 fatty acids such as fish oils.  This inflammatory condition also benefits greatly from antioxidants such as Vitamin A, Vitamin D, Vitamin E, and Vitamin C.

Diagnosed with AD(H)D?  Anxiety?  Bipolar?  Depression?  It could be Pyrrole Disorder.  A high incidence of Pyrrole Disorder is found in individuals with depression, anxiety disorder, ODD, , bipolar disorder and AD(H)D.  Pyrrole Disorder is associated with elevated pyrroles in urine and severe deficiencies of zinc and pyridoxine (Vitamin B-6) throughout the body.  Ask yourself if you are experiencing symptoms of pyroluria. 

 
Testing for pyrrole disorder:  
Second Opinion Physician will arrange to have urine test kits sent to your home to determine your level of urinary pyrroles. 
 
Pyrrole Disorder Treatment:
 
You will be given a customized supplement plan that you may take to your local vitamin supplier or else use our recommended professional sources online. Second Opinion Physician provides product codes, dosages and times per day each supplement should be taken for your specific level of imbalance.
 
Temper Dysregulation Disorder 
 
Many children with severe temper tantrums, learning disabilities and oppositional defiant disorders actually suffer from pyrrole disorder. 
 

Symptoms of Pyrrole Disorder vary but may include:

                Urine

Elevated kryptopyrroles

Mauve colored urine

Digestive

Morning nausea

Tendency to delay or skip breakfast

Very dry skin

Affinity for spicy and salty foods

Body Features

Pale skin, inability to tan

White spots in nail beds

Sensitivity to bright lights

Sensitivity to loud noises

Poor wound healing

Joint pains

Premature graying of hair

Psoriasis

Delicate facial features

“Fruity” breath and/or body odor

Coarse eyebrow hair

Sretch marks (striae) on skin

Long arms, legs and fingers

Mood and Emotions

Extreme mood swings

Severe inner tension

Severe anxiety

Tendency to stay up very late

High irritability and temper

History of underachievement

Histrionic behavior

Severe depression

Fear of airplane travel, tornadoes, etc.

Obsessions with negative thoughts

Dreams and Memory

Little or no dream recall

Poor short-term memory

History of a reading disorder

Immunity and Inflammation

Autoimmune disorders

Severe oxidative stress

Poor growth

Delayed puberty

Spleen-area pain

Frequent infections

Abnormal EEG

Hormonal

Abnormal fat distribution

Abnormal or absent menstrual periods

Poor muscle development

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Natural Remedies for Mood Disorders

Pioneers in the field of Nutrient Therapy, such as Carl Pfeiffer, MD, PhD and William J. Walsh, PhD, President of the Walsh Research Institute, have found abnormalities in and elevated or reduced levels of histamines in the body to be central to many different behavioral or mood disorders, such as bipolar disorder, depression, anxiety, panic disorders, and even classical paranoid .  The effects of being over or under methylated or of having abnormalities in histamine levels are vast and often debilitating… but the good news is that there exists completely safe and natural remedies for these imbalances!  And the power, speed, and efficacy of these natural remedies can be a source of great hope and relief for sufferers of mood disorders, including depression, anxiety, and other upsetting conditions that are not uncommon in an increasingly toxic and often stressful modern way-of-life.

BIOTYPE 1 – Undermethylators (38% of depression population):

Some of the common characteristics of this depressive group are: OCD tendencies, calm exterior but high inner tension, competitive, perfectionistic, addictive tendencies, and high libido.  Undermethylators may be benefited by SSRI medications, but often with side-effects.  The Nutrient Therapy approach would most likely include the addition of methionine or SAMe. These amino acids contribute a methyl compound and increase total serotonin production.  Other important supplements include inositol, B6, calcium, magnesium and vitamin C.

Folic acid is absolutely not recommended for these types.

BIOTYPE 2 – Overmethylators (or “Low-Folate Depressives”) (20% of depressed population):

Some of the commonly recurring characteristics within this population are: high anxiety, panic, noncompetitive in sports or games, food/chemical sensitivities, high musical or artistic ability, underachievement, sleep disorders, and low libido.  This subtype tends to do poorly with methylation and in fact do very poorly with SSRI antidepressants. This is because they have plenty of serotonin, but they lack B12 and Folic Acid. Likewise, SAMe and methionine are not recommended.  An effective nutrient therapy would seek to enhance acetylation and suppress methylation for these patients, folate and niacinamide being excellent supplements for this.

Excellent Podcast Below Featuring William Walsh PhD on Bulletproof Radio Discussing Methylation

One-carbon (methyl) groups are integral to the synthesis of neurotransmitters, genetic expression, metabolism, and other crucial biochemical reactions.  Methylation, also referred to as the methyl/folate ratio, turns cells on and off through histone bodies which are connected to the .  DNA is responsible for the production of proteins which can express in the form of enzymes, hormones, inflammatory cells, neurotransmitters, and more.  Methylation affects anything that is produced by the differentiated cells of the body.  As far as brain function is concerned, methylation is a major player in the synthesis of serotonin, dopamine, and norepinephrine, three neurotransmitters whose proper balancing and healthy levels are essential for the maximized functioning of our brains and for the maintenance of a healthy emotional life.

In overmethylated patients there tends to be an abundance of serotonin, dopamine, and norepinephrine whereas undermethylated patients tend to be depleted in these essential neurotransmitters.  Within the realm of behavioral disorders, what is crucial is the enzyme which is responsible for returning serotonin to the originally releasing neurotransmitter (a process referred to as reuptake).

  • When methylation is high (“”), the enzyme levels that return serotonin back to the releasing neuron are low and there is increased serotonin activity.  When methylation is low (“”), the enzyme levels will be in excess and the serotonin activity will be low.
  • Additionally, overmethylation inhibits expression of the genes, of each cell in the body. It does this by causing a folding of the DNA structures. Undermethylation will cause DNA to unfold, making it more expressive.  Folding of the DNA diminishes the activity of that DNA which are responsible for the daily producing of critical hormones, enzymes and other types of proteins etc. All of these factors contribute to conditions ranging from autism to alzheimers, depression and anxiety. Understanding this new science gives us an opportunity to more successfully utilize natural remedies for mood disorders and healthy brain activity in general.

More than two decades ago, Dr. Pfeiffer studied the metabolism of over 20,000 patients suffering from schizophrenia and kept running into the phenomenon of severely deficient levels of histamine in these patients, later referring to this low histamine syndrome as “histapenia”.  Histapenia was found to be common in his classical paranoid schizophrenic patients, as well as those suffering from anxiety and panic disorders.  The histamine deficiency also coincided with nutrient deficiencies, specifically folic and and/or B12, and with an overload of copper.  Based on these findings, Dr. Pfeiffer enacted an aggressive therapy regime using B12, B3, and folic acid for these patients… and had tremendous success!  The patients experienced dramatic improvements, and Dr. Pfeiffer attributed the success to the elevation of histamine levels.  Ensuing studies have pointed to the role of the methyl/folate ratio and its normalization as being critical to these favorable outcomes.

  • Elevated histamine indicates undermethylation, and there are symptoms which may point to this being the case for an individual, for example: seasonal allergies, obsessive-compulsive tendencies, being strong-willed, perfectionism, and high-libido, just to name a few.
  • Some conditions associated with undermethylation are OCD obsessive compulsive disorder, trichotillomania, oppositional-defiant disorder, competitiveness, bulimia, anorexia, impulsivity (gambling/shopping disorders, etc), depression, schizoaffective disorder, and delusions.

On the other hand, overmethylated persons typically suffer from food/chemical sensitivities, dry eyes, and a severe intolerance to SSRI medications (such as Prozac, Celexa, Lexapro, Luvox, Paxil, Zoloft, etc), and have strong association with anxiety and panic disorders, low motivation, paranoid schizophrenia, hyperactivity, anxious depression, learning disabilities, and even hallucinations.

At Second Opinion Physician we request labs to be done for all patients (appropriate to the information gathered at initial consultation) in order to assess nutrient levels, and which includes testing for methylation levels, so that we might then effectively prescribe natural remedies for mood disorders.

  • If a patient is found to be overmethylated we typically treat with folic acid and B12, plus a focus on dietary considerations (for example, perhaps recommending an increase in animal skin, cartilage, and gelatin consumption in order to provide B vitamins and proteins which naturally counter excess methylation).  B12 and folic acid therapies can noticeably slow down methylation symptoms within 2 weeks to 2 months.
  • If methylation is low, we strive to increase serotonin production naturally, with supplements/nutrients such as B6 and Zinc and may recommend adding methionine to the patient’s diet, which comes naturally from muscle meats.  We may also recommend the addition of SAMe, which is a fast-acting and more readily available methylator.  Patients may see major effects with methionine in about 1-3 months, and even more quickly with SAMe treatment.

Methylation and histamine-level balancing is just one example of the nutrient-based approach to health taken by Second Opinion Physician.  By using natural remedies to balance brain chemistry and improve methylation status we can tackle even the most tenacious mood disorders, behavioral disorders, combat anxiety, and treat depression naturally to create more overall health and emotional balance for otherwise suffering individuals.

Listen to William Walsh PhD Podcast with Bulletproof Radio:

Play

Treating Depression Naturally

…by gaining control over your brain’s biochemistry

Dr. William J. Walsh, PhD is the president of the Walsh Research Institute, an organization “dedicated to unraveling the biochemistry of mental disorders and [the] development of improved clinical treatments through scientific research”.  Dr. Walsh received his PhD in Chemical Engineering, but while working as a prison volunteer he was given the opportunity to study the brain chemistry of convicts and violent offenders and, because of the astounding discoveries made, decided to devote the rest of his career to Nutrient Based Psychiatry & Nutritional Medicine.  Dr. Walsh is very influential and highly regarded in his field, and has become a major proponent of treating depression naturally, as well as using Nutritional Therapy to combat many other mental and behavioral disorders.

Around 1965-1975, there was a revolution in mental health happening around the world.  Psychiatry was shifting its focus from a Freudian-based one, which speculated that children were born as a “blank slate” whose behavior and personality were then formed by their experiences and environment, into a paradigm which acknowledged family history, chemical imbalances, neurotransmitters, and the overall molecular biology of the brain as major factors in “bad behavior”, mental illness, , etc.  Dr. Walsh wondered if this molecular biology could explain much of what was driving the violence and/or mental illness of the convicts that he was working with at the time.  This inquiry led to years upon years of experiments and the accumulation of massive amounts of data, all pointing towards a surprising conclusion… chemical imbalances, and improper levels of trace metals in particular, do indeed account for many of the tendencies of violent criminals and the expression of mental and behavioral disorders.

One example Dr. Walsh gives of a trace metal that has a huge impact on brain function is copper.  Copper is a key factor in the transition of dopamine to norepinephrine, so not having the right amount of copper in your system will lead to unhealthy levels of norepinephrine.  Additionally, it is very important that our bodies have the ability to regulate these levels by flushing excess copper from our system.  Some people do not have these regulatory abilities, and Dr. Walsh was surprised to discover that almost all of the convicts/offenders he was working had copper imbalances… those with who had episodic violent tendencies had very high copper levels, and the sociopathic types had very low copper levels.  This is just one example of the remarkable and pervasive findings of these revolutionary studies.

Additionally surprising was the fact that an entire group of convicts that Dr. Walsh had worked with, when subjected to blood tests in order to assess brain chemistry, returned almost identical results.  All the convicts had Pyrrole Disorder, were dramatically zinc deficient, and all were under methylated (high blood histamine).  Dr. Walsh recalls saying “they’re all the same!” upon receiving results.  This was incredibly surprising news… but also exciting, as these types of imbalances are easily treated with the proper Nutritional Therapy.  These discoveries and more prompted Dr. Walsh to initiate a study of over 500 people, starting with violent offenders and then eventually also taking on children who exhibited violent tendencies.  The treatments were extremely beneficial to the adults, but many would stop compliance after a period of time, thereby negating the positive outcomes.  The children, on the other hand, had extremely high levels of success, with very long-lasting beneficial effects.

One major focus of Dr. Walsh’s is depression.  According to Dr. Walsh, there is a major misconception around depression in the world of Psychiatry.  Depression is usually treated as a “single disorder” whose major foundational factor is low activity in serotonin receptors.  But not all depressions are alike, as Dr. Walsh’s data has shown him.  He points to “five completely different disorders called ‘depression’, only two of which have to do with serotonin”.  It is perfectly logical to conclude that treating depression naturally, thru Nutritional Therapy, could bypass much of the hardship and mishaps which are proliferated by treating each person and each brain as if it were the same… a dangerous approach, as it turns out that undermethylated patients respond very differently to SSRIs (Selective Serotonin Reuptake Inhibitors, most often prescribed for depression) then overmethylated patients, who respond very poorly.  Dr. Walsh even points to school shooting as one of the devastating offshoots of this type of blanket treatment offered for depression, as 40 out of the 50 school shootings of the past 3 decades have been carried out by young men who had functioned quite normally thru life before being put on SSRI antidepressant medications.  Dr. Walsh speculates that a simple blood test may have helped guide the prescribing physicians towards more appropriate treatment, as it could indicate whether or not a patient was overmethylated and therefore at high risk for adverse effects from the SSRIs.

Dr. Walsh believes that “we’re on the verge of a new era of psychiatry where we’ll be able to fix all these psychiatric problems without foreign molecules.  We’ll be able to normalize the brain, without drugs.  That is the era that is just beginning… and my group is trying to speed that up”.  As a matter of fact, his group at one point studied 700 violent children and adults, treated their specific chemical imbalances thru Nutritional Therapy (thereby “normalizing brain chemistry”) and then published the resulting changes in their violent activity.  91% of the families said that violent episodes had diminished, and 58% reported that violent episodes had completely disappeared.  Astounding results.

Dr. Walsh is very clear in pointing out that he is “not opposed to drugs… psychiatric medications have helped millions of people.  It was the best they had for the last 50 years… but now we’re learning how to do things better and without side effects … normalizing the brain instead of putting powerful foreign molecules into the brain.  As science advances, the need for psychiatric drugs will fade away”.

Second Opinion Physician agrees! And we believe that need for drugs is already fading.  SOP is trained in the Walsh Protocol and can advise patients on ways to use Nutritional Therapy and Supplements to combat mental and behavioral disorders, including highly effective ways of treating depression naturally.

The Role of Pyrroles in Depression

#, also known as pyroluria or mauve factor, is a condition in which elevated levels of urinary due to oxidative stress. It is often brought on or exacerbated by physical and emotional distress. This may be the trigger that causes one to suddenly develop an imbalance in the breakdown of hemaglobin. This leads to chronic and vitamin B6 deficiencies due to the fact that pyrroles are aldehyde chelators and they attract and subsequently deplete zinc and B6.  This is a chronic disorder that affects roughly 10% of the population, and is especially prominent in those suffering from behavioral and mood disorders such as , , , bipolar, and .  Unfortunately, while doctors learned about this condition in medical school it is rarely acknowledged or investigated by general practitioners and psychiatrists, much less diagnose. Yet the treatment with supplements is simple and in many cases highly effective.

Some of the common symptoms are: , mood swings, depression, auditory processing disorder, memory loss, joint pain, poor dream recall, Irritable bowel syndrome, as well as being associated with internal stress and low serotonin production. Folks with zinc deficiency can often screen themselves by looking at their nail beds. If there are white clouds under the nail, this is a pretty good sign to get yourself checked out.

Following is an article excerpt from the story of one child’s Kryptopyrrole diagnosis, and she and her family’s journey from daily struggle into thriving and well-being…

Here’s an good example of what to expect with urinary pyrroles from Body and Soul:
Read full article here: Body & Soul, 10% Have This Illness But Most Don’t Know It

“We saw various experts trying to find out what was wrong and received various diagnoses, before taking Sophie to a physiotherapist who did cranial and visceral manipulation. She told me there was a problem with Sophie’s gut and recommended we see a GP who specialised in that area. She diagnosed pyrroles disorder.

Unusually, I had heard of pyrrole, as a friend’s son had it. It’s a genetic blood disorder that results in a dramatic deficiency of zinc, vitamin B6 and arachidonic acid – a long-chain##### fat.

Common symptoms include inability to cope with stress, emotional mood swings and sensitivity to light and sound. It also causes learning difficulties and auditory processing disorder, which means that in a noisy environment, it’s hard to single out the sound you should be listening to. In a classroom environment, that would mean that if other kids were talking, Sophie would struggle to hear the teacher.

It all made perfect sense and, sure enough, the urine test came back positive. The doctor told Sophie: “You poor thing, you really have been having a hard time of it, haven’t you?”, which was probably the best thing she could?have said. It was really nice for Sophie to have someone acknowledge her condition like that.

Sophie, now seven, was prescribed supplements in a dosage accordant with her weight and it made an immediate difference. We saw changes overnight and, although I know our journey is ongoing, it’s been getting better ever since. She was instantly happier, slept better and concentrated better. Before she couldn’t retain information or do spelling but now it was as if that blockage had been unblocked.”