IgG antibodies to the gastric parietal cells are detected in the serum of up to 90% of patients with pernicious anemia.
These are stomach cell auto-antibodies to gastric parietal cells are found in approximately 30% of first degree relatives of patients with pernicious anemia.
Increased levels of gastric parietal cells have been found in patients with hashimoto’s thyroid disease, iron deficiency anemia, alopecia areata, vitiligo and other autoimmune conditions.